RT Journal Article
SR Electronic
T1 Sepsis Management for the Nephrologist
JF Clinical Journal of the American Society of Nephrology
JO CLIN J AM SOC NEPHROL
FD American Society of Nephrology
SP CJN.14381121
DO 10.2215/CJN.14381121
A1 Patel, Sharad
A1 Puri, Nitin
A1 Dellinger, R. Phillip
YR 2022
UL http://cjasn.asnjournals.org/content/early/2022/05/12/CJN.14381121.abstract
AB The definition of sepsis has evolved significantly over the past three decades. Today, sepsis is defined as a dysregulated host immune response to microbial invasion leading to end organ dysfunction. Septic shock is characterized by hypotension requiring vasopressors after adequate fluid resuscitation with elevated lactate. Early recognition and intervention remain hallmarks for sepsis management. We addressed the current literature and assimilated thought regarding optimum initial resuscitation of the patient with sepsis. A nuanced understanding of the physiology of lactate is provided in our review. Physiologic and practical knowledge of steroid and vasopressor therapy for sepsis is crucial and addressed. As blood purification may interest the nephrologist treating sepsis, we have also added a brief discussion of its status.