RT Journal Article
SR Electronic
T1 Mass Transport in High-Flux Hemodialysis
JF Clinical Journal of the American Society of Nephrology
JO CLIN J AM SOC NEPHROL
FD American Society of Nephrology
SP 749
OP 756
DO 10.2215/CJN.09410721
VO 17
IS 5
A1 Mohajerani, Farzad
A1 Clark, William R.
A1 Ronco, Claudio
A1 Narsimhan, Vivek
YR 2022
UL http://cjasn.asnjournals.org/content/17/5/749.abstract
AB An understanding of the processes underlying mass transfer is paramount for the attainment of adequate solute removal in the dialytic treatment of patients with kidney failure. In this review, engineering principles are applied to characterize the physical mechanisms behind the two major modes of mass transfer during hemodialysis, namely diffusion and convection. The manner in which flow rate, dialyzer geometry, and membrane microstructure affect these processes is discussed, with concepts such as boundary layers, effective membrane diffusivity, and sieving coefficients highlighted as critical considerations. The objective is to improve clinicians’ understanding of these concepts as important factors influencing the prescription and delivery of hemodialysis therapy.