RT Journal Article
SR Electronic
T1 APOL1 Nephropathy: From Genetics to Clinical Applications
JF Clinical Journal of the American Society of Nephrology
JO CLIN J AM SOC NEPHROL
FD American Society of Nephrology
SP 294
OP 303
DO 10.2215/CJN.15161219
VO 16
IS 2
A1 Friedman, David J.
A1 Pollak, Martin R.
YR 2021
UL http://cjasn.asnjournals.org/content/16/2/294.abstract
AB Rates of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups. Much of this disparity can now be attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry. These variants greatly increase rates of hypertension-associated ESKD, FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease. We discuss the population genetics of APOL1 risk variants and the clinical spectrum of APOL1 nephropathy. We then consider clinical issues that arise for the practicing nephrologist caring for the patient who may have APOL1 kidney disease.