PT  - JOURNAL ARTICLE
AU  - Khatri, Minesh
AU  - Moon, Yeseon P.
AU  - Scarmeas, Nikolaos
AU  - Gu, Yian
AU  - Gardener, Hannah
AU  - Cheung, Ken
AU  - Wright, Clinton B.
AU  - Sacco, Ralph L.
AU  - Nickolas, Thomas L.
AU  - Elkind, Mitchell S.V.
TI  - The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort
AID  - 10.2215/CJN.01080114
DP  - 2014 Nov 07
TA  - Clinical Journal of the American Society of Nephrology
PG  - 1868--1875
VI  - 9
IP  - 11
4099  - http://cjasn.asnjournals.org/content/9/11/1868.short
4100  - http://cjasn.asnjournals.org/content/9/11/1868.full
SO  - CLIN J AM SOC NEPHROL2014 Nov 07; 9
AB  - Background and objectives Various dietary strategies have been investigated to slow kidney function decline. However, it is unknown whether a Mediterranean diet, which has been associated with improved cardiovascular risk, is associated with change in kidney function.Design, setting, participants, & measurements This study used the Northern Manhattan Study, a prospective, multiethnic, observational cohort of participants who were stroke free at baseline. Data were collected between 1993 and 2008. Serum creatinine measurements were taken a mean 6.9 years apart. A baseline dietary questionnaire was extrapolated into a previously used 9-point scoring system (MeDi). The primary outcome was incident eGFR<60 ml/min per 1.73 m2using the Modification of Diet in Renal Disease formula. A secondary outcome was the upper quartile of annualized eGFR decline (≥2.5 ml/min per 1.73 m2 per year). Conditional logistic regression models adjusted for demographics and baseline vascular risk factors.Results Mean baseline age was 64 years, with 59% women and 65% Hispanics (N=900); mean baseline eGFR was 83.1 ml/min per 1.73 m2. Incident eGFR<60 ml/min per 1.73 m2 developed in 14% . In adjusted models, every 1-point increase in the MeDi score, indicating increasing adherence to a Mediterranean diet, was associated with decreased odds of incident eGFR<60 ml/min per 1.73 m2 (odds ratio, 0.83; 95% confidence interval, 0.71 to 0.96) and decreased odds of being in the upper quartile of eGFR decline (odds ratio, 0.88; 95% confidence interval, 0.79 to 0.98).Conclusions A Mediterranean diet was associated with a reduced incidence of eGFR<60 ml/min per 1.73 m2 and upper quartile of eGFR decline in a multiethnic cohort.