RT Journal Article
SR Electronic
T1 Vascular Effects of Exercise Training in CKD: Current Evidence and Pathophysiological Mechanisms
JF Clinical Journal of the American Society of Nephrology
JO CLIN J AM SOC NEPHROL
FD American Society of Nephrology
SP 1305
OP 1318
DO 10.2215/CJN.13031213
VO 9
IS 7
A1 Van Craenenbroeck, Amaryllis H.
A1 Van Craenenbroeck, Emeline M.
A1 Kouidi, Evangelia
A1 Vrints, Christiaan J.
A1 Couttenye, Marie M.
A1 Conraads, Viviane M.
YR 2014
UL http://cjasn.asnjournals.org/content/9/7/1305.abstract
AB Cardiovascular disease remains the main cause of morbidity and mortality in patients with CKD, an observation that cannot be explained by the coexistence of traditional risk factors alone. Recently, other mechanisms, such as alterations in nitric oxide bioavailability, impaired endothelial repair mechanisms, inflammation, and oxidative stress (all characteristic in CKD), have gained much attention as mediators for the increased cardiovascular risk. Regular physical training is a valuable nonpharmacological intervention for primary and secondary prevention of cardiovascular disease. Likewise, the benefits of exercise training on exercise capacity and quality of life are increasingly recognized in patients with CKD. Furthermore, exercise training could also influence potential reversible mechanisms involved in atherosclerosis and arteriosclerosis. After discussing briefly the general concepts of vascular disease in CKD, this review provides an overview of the current evidence for the effects of exercise training at both clinical and preclinical levels. It concludes with some practical considerations on exercise training in this specific patient group.