Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, Jaber BL; Acute Kidney Injury Advisory Group of the American Society of Nephrology: World incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol 8: 1482–1493, 2013.
In the original investigation that appeared in the September issue of CJASN (1), there was an error in the selection of studies that used a Kidney Disease Improving Global Outcomes (KDIGO)–equivalent serum creatinine–based criterion to define AKI. In the study selection process, we inadvertently included more than one time seven publications on five cohort studies of adults that originated from Australia and New Zealand, Italy, Brazil, and the United States. As a result, instead of the original 312 cohort studies reported in the article, Figure 1 in ref. 1 displaying the study selection should read that 305 cohort studies were included in the meta-analysis (48,774,892 patients), with a subset of 147 studies (3,212,925 patients) using a KDIGO-equivalent AKI definition. The characteristics of the subset of 147 studies are displayed in the revised Supplemental Tables 3 and 4 and revised Table 1 in ref. 1. We have repeated all the random effects model meta-analyses and metaregressions, which provided essentially comparable results to our original findings. These results are summarized in the revised Figures 1–5 and Tables 2–5 in ref. 1. The revised tables and figures are available in Supplemental Material in ref. 1 (available online). In brief, after exclusion of seven publications, the overall pooled incidence rate of AKI dropped from 23.2% (95% confidence interval [95% CI], 21.0 to 25.7) to 22.8% (95% CI, 20.5 to 25.3), and among studies of adults, it dropped from 21.6% (95% CI, 19.3 to 24.1) to 21.0% (95% CI, 18.7 to 23.6). The pooled AKI-associated mortality dropped from 23.0% (95% CI, 21.3 to 24.8) to 22.4% (95% CI, 20.5 to 24.4), and among studies of adults, it dropped from 23.9% (95% CI, 22.1 to 25.7) to 23.3% (95% CI, 21.3 to 25.5). On metaregressions, the association of the pooled AKI and associated mortality rate with aggregate study- and country-level characteristics persisted. In summary, based on our revised analyses yielding comparable results, we stand by our conclusions.
Footnotes
This article contains supplemental material online at http://cjasn.asnjournals.org/lookup/suppl/doi:10.2215/CJN.03050314/-/DCSupplemental.
- Copyright © 2014 by the American Society of Nephrology
Reference
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