Article Figures & Data
Figures
- Figure 1.
Identification, exclusion, and analysis of infants for the study.
- Figure 2.
AKI occurrence by gestational age among very low birth weight infants; 80% of infants who experienced AKI were born at <28 weeks gestational age, whereas 73% of infants who did not experience AKI were born at ≥28 weeks gestational age (odds ratio, 10.6; 95% confidence interval, 6.8 to 16.7; c statistic=0.76; 95% confidence interval, 0.72 to 0.81).
Tables
AKI Stage Definition 0 No significant change in creatinine 1 ↑ SCr by 0.3 mg/dl within 48 h or ↑ in SCr by 150% to <200% from previous trough 2 ↑ in SCr by 200% to <300% of previous trough 3 ↑ in SCr≥300% of previous trough or SCr≥2.5 mg/dl or RRT SCr, serum creatinine.
- Table 2.
Patient demographics with mean testing for infants who did and did not experience AKI
Characteristic All Patients (n=455) AKI (n=181) No AKI (n=274) P Mean (SD) Range Mean (SD) Range Mean (SD) Range Gestational age (wk) 27.7 (3) 22–37 25.7 (2.4) 22–33 29.0 (2.6) 24–37 <0.001 Birth weight (g) 1016 (296) 370–1495 816 (253) 370–1470 1148 (245) 400–1495 <0.001 Sex (% boys) 51 54 49 0.33 Apgar (1 min) 4.9 (2.7) 0–9 4.0 (2.6) 0–9 5.4 (2.5) 0–9 <0.001 Apgar (5 min) 6.9 (2.0) 0–9 6.0 (2.2) 0–9 7.4 (1.7) 2–9 <0.001 SGA (%) 22 14 26 0.002 CRIB II scorea 9.5 (3.9) 2–19 12.1 (3.6) 3–19 7.6 (3.0) 2–17 <0.001 Length of stay (d) 68 (41) 3–307 95 (69–114)b 3–307 46 (31–69)b 3–175 <0.001 Initial creatinine (mg/dl) 0.74 (0.14) 0.4–1.5 0.76 (0.15) 0.4–1.1 0.72 (0.13) 0.5–1.5 0.001 Mortality (%) 8 14 3 <0.001 SGA, small for gestational age; CRIB II, updated clinical risk index for babies score.
↵a CRIB II scores were missing in 18.5% of patients. For all patients, n=371. For patients with AKI, n=157. For patients with no AKI, n=214.
↵b All results are reported as mean and SD except length of stay, which is reported as median and interquartile range.
Factor OR 95% CI P Univariable analyses AKI 4.94 2.26 to 10.81 <0.001 Apgar (1 min) 0.83 0.72 to 0.96 0.01 Apgar (5 min) 0.74 0.64 to 0.87 <0.001 Birth weight (100 g) 0.81 0.72 to 0.92 0.001 CRIB II 1.17 1.06 to 1.29 0.001 Gestational age (wk) 0.80 0.70 to 0.92 0.001 Preeclampsia 0.60 0.18 to 2.01 0.41 Race (non-Caucasian) 1.17 0.58 to 2.35 0.66 Sex (boys) 1.71 0.84 to 3.48 0.14 SGA 0.90 0.38 to 2.14 0.82 Multivariable analyses (final model) AKI 4.00 1.39 to 11.52 0.01 Birth weight (100 g) 1.39 1.01 to 1.91 0.04 CRIB II 1.34 1.06 to 1.69 0.02 SGA 4.38 1.39 to 13.80 0.01 OR, odds ratio; 95% CI, 95% confidence interval; CRIB II, updated clinical risk index for babies; SGA, small for gestational age.
Factor Days 95% CI P Univariable analyses AKI (occurrence) 53.3 49.5 to 57.1 <0.001 AKI (stage 1 only) 39.4 32.7 to 46.1 <0.001 AKI (no. of episodes) 19.1 16.3 to 22.0 <0.001 Apgar (1 min) −3.6 −4.9 to −2.3 <0.001 Apgar (5 min) −5.4 −7.1 to −3.6 <0.001 Birth weight (100 g) −9.2 −10.1 to −8.4 <0.001 CRIB II 11.2 3.8 to 18.7 0.003 Gestational age (wk) −9.4 −10.3 to −8.6 <0.001 Preeclampsia −2.6 −12.8 to 7.5 0.61 Race (non-Caucasian) −1.7 −8.9 to 5.5 0.64 Sex (boys) 3.3 −3.7 to 10.4 0.36 SGA −24.9 −32.9 to −16.9 <0.001 Multivariable analyses (final models) AKI (occurrence) 11.7 5.1 to 18.4 0.001 Birth weight (100 g) −2.9 −4.8 to −1.1 0.002 CRIB II 1.1 −0.7 to 3.0 0.23 Gestational age (wk) −5.1 −7.6 to −2.6 <0.001 AKI (stage 1 only) 5.4 −0.8 to 11.5 0.09 Birth weight (100 g) −2.0 −3.6 to −0.3 0.02 CRIB II 1.9 0.3 to 3.6 0.02 Gestational age (wk) −5.7 −7.9 to −3.6 <0.001 AKI (no. of episodes) 4.9 2.0 to 7.7 0.001 Birth weight (100 g) −3.0 −4.8 to −1.1 0.002 CRIB II 1.4 −0.5 to 3.2 0.15 Gestational age (wk) −4.8 −7.3 to −2.3 <0.001 CRIB II, updated clinical risk index for babies; SGA, small for gestational age.
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