Article Figures & Data
Figures
- Figure 1.
Kaplan-Meier (A) graft survival and (B) patient survival of KRT recipients with the ESW and CSM immunosuppression regimen.
- Figure 2.
Graft function comparison expressed as (A) serum creatinine (mg/dl) and (B) eGFR (ml/min per 1.73 m2) of KRT recipients with the ESW and CSM immunosuppression regimen. The P value was not statistically significant for all time points.
- Figure 3.
Graft function comparison using eGFR (ml/min per 1.73 m2) of KRT recipients with the ESW and CSM immunosuppression regimen by dividing them according to organ source: (A) living donor (LD) and (B) deceased donor (DD). The P value was not statistically significant for all time points.
Tables
ESW (n = 59) CSM (n = 54) P Recipient age (years) 42 + 13 43 + 12 0.975 male 66% (n = 39) 59% (32) 0.452 ethnicity white 78% (46) 81% (44) 0.642 African American 19% (11) 11% (6) 0.263 others 3% (2) 8% (4) 0.341 ESRD diagnosis GN 34% (20) 48% (26) 0.123 congenital 24% (14) 21% (11) 0.667 hypertension 17% (10) 11% (6) 0.373 diabetes mellitus 13% (8) 7% (4) 0.289 others 12% (7) 13% (7) 0.859 PRA 34 + 25 37 + 31 0.562 HLA mismatch(A,B,DR) 3.4 + 1.7 3.3 + 1.8 0.821 follow-up (days) 1105 (118 to 2105) 1786 (31 to 2608) <0.0001 time on HD (years) 2.6 (1.0 to 6.0) 1.6 (0.4 to 5.7) 0.422 graft survival first Tx (days) 3249 (3 to 10,105) 2892 (8 to 12,784) 0.601 pre-emptive KRT 15% (9) 17% (9) 0.837 number of Tx 2 87% (51) 83% (45) 0.644 3 8% (5) 13% (7) 0.439 4 5% (3) 4% (2) 0.721 Donor living donor 37% (22) 31% (17) 0.516 deceased donor 63% (37) 69% (37) 0.516 age (years) 35 + 15 37 + 13 0.455 male 49% (29) 59% (32) 0.281 BMI 27 + 5 26 + 5 0.626 ethnicity white 88% (52) 85% (46) 0.644 African American 9% (5) 11% (6) 0.636 others 3% (2) 4% (2) 0.928 cause of death trauma 35% (13) 38% (14) 0.809 anoxia 41% (15) 32% (12) 0.468 CVA 19% (7) 27% (10) 0.789 others 5% (2) 3% (1) 0.555 Kidney delayed graft function 7% (4) 9% (5) 0.722 pulsatile perfusion yes 78% (29) 68% (25) 0.295 no 14% (5) 19% (7) 0.528 unknown 8% (3) 13% (5) 0.454 total warm ischemia time (minutes) 33 + 5 31 + 5 0.103 cold ischemia time (hours) 16 + 7 14 + 5 0.165 ESW CSM P Biopsy proven rejection 20% (n = 12) 26% (14) 0.509 Time to rejection (days) 63 (14 to 1258) 205 (6 to 1285) 0.819 Type of rejection acute cellular rejection 92% (11) 72% (10) 0.330 acute antibody mediated rejection 8% (1) 28% (4) 0.330 Graft loss 7% (4) 15% (8) 0.231 Cause for current graft loss rejection 25% (1) 50% (4) 0.575 BK nephropathy 25% (1) 0 death with functioning graft 50% (2) 50% (4) 1.00 Cumulative steroid exposure prior to recent Tx (days) 3834 (3 to 10,105) 3600 (8 to 12,784) 0.552 Cause of prior graft loss chronic transplant glomerulopathy 68% (40) 79% (43) 0.363 rejection 17% (10) 13% (7) 0.839 glomerulonephritis 5% (3) 4% (2) 0.934 others 10% (6) 4% (2) 0.408 Metabolic Profile systolic blood pressure (mmHg) 128 + 12 129 + 17 0.792 diastolic blood pressure (mmHg) 72 + 12 74 + 11 0.314 serum albumin (gm/dl) 4 + 0.5 3.7 + 0.5 0.005 fasting blood glucose (mg/dl) 104 + 27 101 + 30 0.741 serum cholesterol (mg/dl) 154 + 33 153 + 34 0.866 serum LDL (mg/dl) 84 + 29 80 + 22 0.457 post transplant diabetes mellitus 1.6% (1) 11% (6) 0.051 anti lipid therapy 44% (26) 70% (38) 0.007 no. of blood pressure medications 1.8 + 1 2.6 + 1.3 0.004 bisphosphonate therapy 10% (6) 35% (19) 0.010
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Early Steroid Withdrawal in Repeat Kidney Transplantation
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