Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow CJASN on Twitter
  • CJASN RSS
  • Community Forum
Original ArticlesChronic Kidney Disease
You have accessRestricted Access

Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney Disease

Sharon M. Moe, Miriam P. Zidehsarai, Mary A. Chambers, Lisa A. Jackman, J. Scott Radcliffe, Laurie L. Trevino, Susan E. Donahue and John R. Asplin
CJASN February 2011, 6 (2) 257-264; DOI: https://doi.org/10.2215/CJN.05040610
Sharon M. Moe
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miriam P. Zidehsarai
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary A. Chambers
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa A. Jackman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Scott Radcliffe
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laurie L. Trevino
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan E. Donahue
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John R. Asplin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

Summary

Background and objectives Patients with advanced chronic kidney disease (CKD) are in positive phosphorus balance, but phosphorus levels are maintained in the normal range through phosphaturia induced by increases in fibroblast growth factor-23 (FGF23) and parathyroid hormone (PTH). This provides the rationale for recommendations to restrict dietary phosphate intake to 800 mg/d. However, the protein source of the phosphate may also be important.

Design, setting, participants, & measurements We conducted a crossover trial in nine patients with a mean estimated GFR of 32 ml/min to directly compare vegetarian and meat diets with equivalent nutrients prepared by clinical research staff. During the last 24 hours of each 7-day diet period, subjects were hospitalized in a research center and urine and blood were frequently monitored.

Results The results indicated that 1 week of a vegetarian diet led to lower serum phosphorus levels and decreased FGF23 levels. The inpatient stay demonstrated similar diurnal variation for blood phosphorus, calcium, PTH, and urine fractional excretion of phosphorus but significant differences between the vegetarian and meat diets. Finally, the 24-hour fractional excretion of phosphorus was highly correlated to a 2-hour fasting urine collection for the vegetarian diet but not the meat diet.

Conclusions In summary, this study demonstrates that the source of protein has a significant effect on phosphorus homeostasis in patients with CKD. Therefore, dietary counseling of patients with CKD must include information on not only the amount of phosphate but also the source of protein from which the phosphate derives.

  • Received June 7, 2010.
  • Accepted September 8, 2010.
  • Copyright © 2011 by the American Society of Nephrology
View Full Text
PreviousNext
Back to top

In this issue

Clinical Journal of the American Society of Nephrology: 6 (2)
Clinical Journal of the American Society of Nephrology
Vol. 6, Issue 2
1 Feb 2011
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in CJASN.
Enter multiple addresses on separate lines or separate them with commas.
Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney Disease
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney Disease
Sharon M. Moe, Miriam P. Zidehsarai, Mary A. Chambers, Lisa A. Jackman, J. Scott Radcliffe, Laurie L. Trevino, Susan E. Donahue, John R. Asplin
CJASN Feb 2011, 6 (2) 257-264; DOI: 10.2215/CJN.05040610

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney Disease
Sharon M. Moe, Miriam P. Zidehsarai, Mary A. Chambers, Lisa A. Jackman, J. Scott Radcliffe, Laurie L. Trevino, Susan E. Donahue, John R. Asplin
CJASN Feb 2011, 6 (2) 257-264; DOI: 10.2215/CJN.05040610
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Summary
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosures
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

Original Articles

  • Trends in Discard of Kidneys from Hepatitis C Viremic Donors in the United States
  • Availability, Accessibility, and Quality of Conservative Kidney Management Worldwide
  • Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis
Show more Original Articles

Chronic Kidney Disease

  • NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD
  • Effect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes
  • Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD
Show more Chronic Kidney Disease

Cited By...

  • Effect of Phosphate-Specific Diet Therapy on Phosphate Levels in Adults Undergoing Maintenance Hemodialysis: A Systematic Review and Meta-Analysis
  • Dietary Therapy for Managing Hyperphosphatemia
  • Nephropathic Cystinosis: A Distinct Form of CKD-Mineral and Bone Disorder that Provides Novel Insights into the Regulation of FGF23
  • Potassium Homeostasis, Chronic Kidney Disease, and the Plant-Enriched Diets
  • High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss
  • Dietary Phosphorus and FGF23: Is More Restriction Better?
  • Short-Term Effects of Very-Low-Phosphate and Low-Phosphate Diets on Fibroblast Growth Factor 23 in Hemodialysis Patients: A Randomized Crossover Trial
  • Metabolic Acidosis in a Patient with CKD
  • Efficacy and Safety of Tenapanor in Patients with Hyperphosphatemia Receiving Maintenance Hemodialysis: A Randomized Phase 3 Trial
  • Lack of Awareness of Dietary Sources of Phosphorus Is a Clinical Concern
  • Phosphorus in kidney disease: Culprit or bystander?
  • Phosphorus binders: The new and the old, and how to choose
  • Twenty-Four-Hour Urine Phosphorus as a Biomarker of Dietary Phosphorus Intake and Absorption in CKD: A Secondary Analysis from a Controlled Diet Balance Study
  • Phosphate Additive Avoidance in Chronic Kidney Disease
  • Dietary Protein as Kidney Protection: Quality or Quantity?
  • Phosphate Toxicity in CKD: The Killer among Us
  • Mineral (Mal)Adaptation to Kidney Disease--Young Investigator Award Address: American Society of Nephrology Kidney Week 2014
  • Rationale and Approaches to Phosphate and Fibroblast Growth Factor 23 Reduction in CKD
  • Association of dietary phosphate and serum phosphorus concentration by levels of kidney function
  • The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort
  • Effect of dietary phosphate intake on the circadian rhythm of serum phosphate concentrations in chronic kidney disease: a crossover study
  • The Use of Fibroblast Growth Factor 23 Testing in Patients with Kidney Disease
  • Lower bioavailability of plant-derived phosphorus
  • Reply to MF McCarty
  • High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III
  • Dietary phosphorus intake and health1-3
  • Assessing the Health Impact of Phosphorus in the Food Supply: Issues and Considerations
  • A Patient with CKD and Poor Nutritional Status
  • The Connection between Dietary Phosphorus, Cardiovascular Disease, and Mortality: Where We Stand and What We Need to Know
  • 24-Hour Urine Phosphorus Excretion and Mortality and Cardiovascular Events
  • Effects of Dietary Phosphate Restriction and Phosphate Binders on FGF23 Levels in CKD
  • Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy1,3
  • Risk Factor Paradox in CKD and ESRD: Does a Healthy Lifestyle Matter?
  • The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores
  • Acute Effects of Very-Low-Protein Diet on FGF23 Levels: A Randomized Study
  • Interaction of Time-Varying Albumin and Phosphorus on Mortality in Incident Dialysis Patients
  • Phosphate and CVD: It's All in What's on the Table
  • Source Matters: From Phosphorus Load to Bioavailability
  • Google Scholar

Similar Articles

Related Articles

  • Source Matters: From Phosphorus Load to Bioavailability
  • PubMed
  • Google Scholar

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Trainee of the Year
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • CJASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About CJASN
  • CJASN Email Alerts
  • CJASN Key Impact Information
  • CJASN Podcasts
  • CJASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe

© 2021 American Society of Nephrology

Print ISSN - 1555-9041 Online ISSN - 1555-905X

Powered by HighWire