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Original ArticlesDialysis
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Role of Residual Kidney Function and Convective Volume on Change in β2-Microglobulin Levels in Hemodiafiltration Patients

E. Lars Penne, Neelke C. van der Weerd, Peter J. Blankestijn, Marinus A. van den Dorpel, Muriel P.C. Grooteman, Menso J. Nubé, Piet M. ter Wee, Renée Lévesque and Michiel L. Bots
CJASN January 2010, 5 (1) 80-86; DOI: https://doi.org/10.2215/CJN.03340509
E. Lars Penne
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Neelke C. van der Weerd
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Peter J. Blankestijn
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Marinus A. van den Dorpel
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Muriel P.C. Grooteman
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Menso J. Nubé
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Piet M. ter Wee
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Renée Lévesque
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Michiel L. Bots
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    Figure 1.

    Changes in predialysis serum β2M levels by dialysis modality in patients (A) without and (B) with RKF. Bars represent 95% CI. #P < 0.001 (for difference between HDF and HD).

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    Figure 2.

    Relationship between baseline GFR and change in β2M level from baseline to 6 mo in HDF patients adjusted for participating center. Baseline GFR is subdivided in tertiles. Bars represent 95% CI. P value for trend <0.001.

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    Table 1.

    Patient characteristics at baselinea

    HDF (n = 199)HD (n = 207)
    Gender (% male)6265
    Age (yr)66 (53 to 74)66 (55 to 75)
    History of cardiovascular disease (%)4544
    Diabetes mellitus (%)2520
    Dialysis vintage (yr)1.7 (0.8 to 3.4)2.2 (1.1 to 4.1)
    Body mass index (kg/m2)24.9 ± 4.725.0 ± 4.2
    Systolic blood pressure (mmHg)147 ± 21150 ± 21
    Diastolic blood pressure (mmHg)76 ± 1377 ± 11
    Vascular access (% arteriovenous fistula)7680
    Treatment time (min)240 (210 to 240)240 (210 to 240)
    Blood flow (ml/min)302 ± 37299 ± 43
    Dialysis Kt/Vurea1.39 ± 0.221.36 ± 0.17
    RKF (%)b5855
    Urinary volume (ml/24 h)c700 (288 to 1150)750 (350 to 1210)
    GFR (ml/min/1.73 m2)c,d3.1 (1.3 to 5.6)3.3 (1.1 to 5.4)
    Hemoglobin (mmol/L)7.4 ± 0.87.4 ± 0.7
    Phosphorus (mmol/L)1.69 ± 0.521.63 ± 0.49
    Albumin (g/L)36.5 ± 4.636.7 ± 4.5
    β2M (mg/L)29.5 ± 1231.9 ± 13
    • ↵a Values represent mean ± SD, median (interquartile range), or proportion (%). To convert hemoglobin in mmol/L to g/dl, divide by 0.62; phosphate in mmol/L to mg/dl, divide by 0.323; and albumin in g/L to g/dl, divide by 10.

    • ↵b Defined as the proportion of patients with diuresis >100 ml/24 h.

    • ↵c In selection of patients with RKF.

    • ↵d Mean of urea and creatinine clearance.

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    Table 2.

    Results from univariable and multivariable linear regression analysesa of 6-mo change in β2M in HDF patients

    DeterminantUnivariable RegressionMultivariable Regression
    Bb95% CIB95% CI
    Gender (male)1.3−2.0 to 4.6
    Age (per 10 yr)0.2−0.9 to 1.3
    History of cardiovascular disease2.5−0.7 to 5.71.9−1.3 to 5.2
    Diabetes mellitus2.7−1.0 to 6.31.7−2.1 to 5.5
    Dialysis vintage (per yr)−0.4−0.9 to 0.2
    Body mass index (per kg/m2)0.0−0.3 to 0.3
    Arteriovenous fistula0.2−3.5 to 3.9
    Convective volume (per L/treatment)0.1−0.3 to 0.60.3−0.2 to 0.7
    Dialysis frequency (per session/wk)−6.3−12.7 to 0.1−3.7−10 to 3.0
    GFR (per ml/min/1.73 m2)0.90.5 to 1.4c0.90.4 to 1.5c
    Serum albumin (per g/dl)−0.2−0.7 to 0.2
    • ↵a Adjusted for participating center.

    • ↵b The regression coefficient (B) reflects the change in β2M levels between baseline and 6 mo. Positive values of B indicate smaller decreases in β2M during the study period.

    • ↵c P < 0.001.

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Clinical Journal of the American Society of Nephrology
Vol. 5, Issue 1
1 Jan 2010
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Role of Residual Kidney Function and Convective Volume on Change in β2-Microglobulin Levels in Hemodiafiltration Patients
E. Lars Penne, Neelke C. van der Weerd, Peter J. Blankestijn, Marinus A. van den Dorpel, Muriel P.C. Grooteman, Menso J. Nubé, Piet M. ter Wee, Renée Lévesque, Michiel L. Bots
CJASN Jan 2010, 5 (1) 80-86; DOI: 10.2215/CJN.03340509

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Role of Residual Kidney Function and Convective Volume on Change in β2-Microglobulin Levels in Hemodiafiltration Patients
E. Lars Penne, Neelke C. van der Weerd, Peter J. Blankestijn, Marinus A. van den Dorpel, Muriel P.C. Grooteman, Menso J. Nubé, Piet M. ter Wee, Renée Lévesque, Michiel L. Bots
CJASN Jan 2010, 5 (1) 80-86; DOI: 10.2215/CJN.03340509
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