Article Figures & Data
Figures
- Figure 1.
Roles of CFTR and NKCC1 in cyst formation in polycystic kidney disease (PKD) embryonic kidneys in metanephric culture. (A) Cyst formation in wild-type (+/+), heterozygous (+/−), and homozygous (−/−) embryonic day 15.5 (E15.5) Pkd1 kidneys that were cultured for 4 d in 100 μM 8-Br-cAMP. (B) Effect of CFTR genotype on cAMP-dependent cyst formation in E15.5 wild-type and Pkd1 −/− kidneys that were cultured for 4 d in 100 μM 8-Br-cAMP. (C) Effect of 100 μM bumetanide treatment on cAMP-dependent cyst formation in E15.5 wild-type and Pkd1 +/− and −/− kidneys that were cultured for 4 d in 100 μM 8-Br-cAMP. Bar graphs represent the average fractional cyst areas in the indicated number of animals. Images of representative kidneys are shown above the bars. ***P < 0.001 versus the control for each group. Based in part on data by Magenheimer et al. (13).
- Figure 2.
Pathways from cAMP and calcium to extracellular signal–regulated kinase (ERK) and cell proliferation. (Left) Normal signaling pathways. (Right) Signaling pathways in PKD. PC, polycystin; GF, growth factor; solid lines, active pathways; dotted lines, diminished pathways. Arrows by ERK indicate decreased (left) or increased (right) activity. Based on data by Yamaguchi et al. (4) and adapted from reference (52).
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