Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • Kidney Week Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Feedback
    • Reprint Information
    • Subscriptions
  • ASN Kidney News
  • Other
    • ASN Publications
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • ASN Publications
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • Kidney Week Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Feedback
    • Reprint Information
    • Subscriptions
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow CJASN on Twitter
  • CJASN RSS
  • Community Forum
Dialysis
You have accessRestricted Access

Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients

Cheuk-Chun Szeto, Bonnie Ching-Ha Kwan, Kai-Ming Chow, Ka-Bik Lai, Kwok-Yi Chung, Chi-Bon Leung and Philip Kam-Tao Li
CJASN March 2008, 3 (2) 431-436; DOI: https://doi.org/10.2215/CJN.03600807
Cheuk-Chun Szeto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bonnie Ching-Ha Kwan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kai-Ming Chow
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ka-Bik Lai
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kwok-Yi Chung
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chi-Bon Leung
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philip Kam-Tao Li
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

Abstract

Background and objectives: Systemic inflammatory state is a hallmark of peritoneal dialysis (PD) patients, but its etiology remains obscure. Because circulating microbial products are an important cause of systemic immune activation in other conditions such as HIV infection, it was hypothesized that endotoxemia is a cause of systemic inflammatory state and atherosclerosis in PD patients.

Design, setting, participants, & measurements: Plasma lipopolysaccharide (LPS) levels in 30 consecutive new PD patients were measured. The result was compared with serum C-reactive protein (CRP) level, peritoneal transport status, history of pre-existing cardiovascular diseases, and carotid intima media thickness (IMT) by Doppler ultrasound.

Results: Among the 30 PD patients, there were 17 men. The average age was 53.7 ± 15.1 yr. The average endotoxin concentration of PD patients was 0.44 ± 0.18 EU/ml, which was significantly higher than that of patients with chronic kidney disease secondary to Ig-A nephropathy (IgAN) (0.035 ± 0.009 EU/ml, P < 0.0001) and the controls (0.013 ± 0.007 EU/ml, P < 0.0001). In PD patients, plasma LPS concentration had a significant correlation with serum CRP (r = 0.415, P = 0.025) and serum albumin level (r = −0.394, P = 0.034). In contrast, plasma LPS level did not correlate with Charlson's Comorbidity Index, peritoneal transport characteristics, or nutritional indices. Patients with pre-existing cardiovascular disease (CVD) had higher plasma LPS level than those without CVD (0.53 ± 0.19 versus 0.36 ± 0.16 EU/ml, P = 0.016). Plasma LPS level correlated with carotid IMT (r = 0.438, P = 0.016).

Conclusions: It was found that endotoxemia was probably common in PD patients, and the degree of circulating endotoxemia might be related to the severity of systemic inflammation and features of atherosclerosis. This result suggests that endotoxemia may have a contributory role to the systemic inflammatory state and accelerated atherosclerosis in PD patients.

  • Received August 27, 2007.
  • Accepted December 27, 2007.
  • Copyright © 2008 by the American Society of Nephrology
View Full Text
PreviousNext
Back to top

In this issue

Clinical Journal of the American Society of Nephrology
Vol. 3, Issue 2
March 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in CJASN.
Enter multiple addresses on separate lines or separate them with commas.
Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients
Cheuk-Chun Szeto, Bonnie Ching-Ha Kwan, Kai-Ming Chow, Ka-Bik Lai, Kwok-Yi Chung, Chi-Bon Leung, Philip Kam-Tao Li
CJASN Mar 2008, 3 (2) 431-436; DOI: 10.2215/CJN.03600807

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients
Cheuk-Chun Szeto, Bonnie Ching-Ha Kwan, Kai-Ming Chow, Ka-Bik Lai, Kwok-Yi Chung, Chi-Bon Leung, Philip Kam-Tao Li
CJASN Mar 2008, 3 (2) 431-436; DOI: 10.2215/CJN.03600807
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Patients and Methods
    • Results
    • Discussion
    • Disclosures
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

  • Defining Left Ventricular Hypertrophy in Children on Peritoneal Dialysis
  • Cardiac Geometry in Children Receiving Chronic Peritoneal Dialysis: Findings from the International Pediatric Peritoneal Dialysis Network (IPPN) Registry
  • Geographic and Educational Factors and Risk of the First Peritonitis Episode in Brazilian Peritoneal Dialysis Study (BRAZPD) Patients
Show more Dialysis

Cited By...

  • The Phosphate Binder Ferric Citrate Alters the Gut Microbiome in Rats with Chronic Kidney Disease
  • Systemic Endotoxin in Peritoneal Dialysis Patients
  • Circulating Bacterial Fragments as Cardiovascular Risk Factors in CKD
  • Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins
  • Gut Microbiota in Cardiovascular Health and Disease
  • Urea, a true uremic toxin: the empire strikes back
  • Associations of Soluble CD14 and Endotoxin with Mortality, Cardiovascular Disease, and Progression of Kidney Disease among Patients with CKD
  • Endotoxin detection in end-stage kidney disease
  • Molecular and Cellular Mechanisms Responsible for Cellular Stress and Low-grade Inflammation Induced by a Super-low Dose of Endotoxin
  • The Gut Microbiome, Kidney Disease, and Targeted Interventions
  • Molecular Mechanism Responsible for the Priming of Macrophage Activation
  • Molecular Mechanisms Responsible for the Reduced Expression of Cholesterol Transporters From Macrophages by Low-Dose Endotoxin
  • Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide
  • The Impact of Antihypertensive Drug Therapy on Endotoxemia in Elderly Patients with Chronic Kidney Disease
  • Effect of Phosphate Binders on Serum Inflammatory Profile, Soluble CD14, and Endotoxin Levels in Hemodialysis Patients
  • Hemodynamic Effects of Peritoneal Dialysis
  • Circulating Endotoxemia: A Novel Factor in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease
  • PERITONEAL DIALYSIS IS NOT ASSOCIATED WITH MYOCARDIAL STUNNING
  • ENDOTOXEMIA IS ASSOCIATED WITH BETTER CLINICAL OUTCOME IN INCIDENT CHINESE PERITONEAL DIALYSIS PATIENTS: A PROSPECTIVE COHORT STUDY
  • Google Scholar

Similar Articles

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Trainee of the Year
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • CJASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About CJASN
  • CJASN Email Alerts
  • CJASN Key Impact Information
  • CJASN Podcasts
  • CJASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe to ASN Journals

© 2022 American Society of Nephrology

Print ISSN - 1555-9041 Online ISSN - 1555-905X

Powered by HighWire