Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease

eGFR is measured in milliliters per minute per 1.73 m². The most recent eGFR measurement in the 365-day period was before the cohort entry date (including the cohort entry date). eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation: 141×min([serum creatinine concentration in micromoles per liter per 88.4]/ĸ, 1)^α×max([serum creatinine concentration in micromoles per liter per 88.4]/ĸ, 1)^−1.209×0.993^Age×1.018 [if a woman]. ĸ=0.7 if a woman and 0.9 if a man; α=−0.329 if a woman and −0.411 if a man. Min is the minimum of serum creatinine concentration/ĸ or one; max is the maximum of serum creatinine concentration/ĸ or one. On the basis of recent Ontario Renal Network guidelines, race was not factored into the calculation of eGFR.