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Risk Factors for CKD Progression

Overview of Findings from the CRIC Study

Mary Hannan, Sajid Ansari, Natalie Meza, Amanda H. Anderson, Anand Srivastava, Sushrut Waikar, Jeanne Charleston, Matthew R. Weir, Jonathan Taliercio, Edward Horwitz, Milda R. Saunders, Katherine Wolfrum, Harold I. Feldman, James P. Lash, Ana C. Ricardo and the CRIC Study Investigators
CJASN April 2021, 16 (4) 648-659; DOI: https://doi.org/10.2215/CJN.07830520
Mary Hannan
1Department of Medicine, University of Illinois, Chicago, Illinois
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Sajid Ansari
1Department of Medicine, University of Illinois, Chicago, Illinois
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Natalie Meza
1Department of Medicine, University of Illinois, Chicago, Illinois
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Amanda H. Anderson
2Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana
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Anand Srivastava
3Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
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Sushrut Waikar
4Nephrology Section, Boston University Medical Center, Boston, Massachusetts
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Jeanne Charleston
5Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
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Matthew R. Weir
6Division of Nephrology, Department of Medicine, University of Maryland, Baltimore, Maryland
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Jonathan Taliercio
7Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio
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Edward Horwitz
8Division of Nephrology, MetroHealth, Cleveland, Ohio
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Milda R. Saunders
9Department of Medicine, The University of Chicago, Chicago, Illinois
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Katherine Wolfrum
10Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
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Harold I. Feldman
11Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
12Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
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James P. Lash
1Department of Medicine, University of Illinois, Chicago, Illinois
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Ana C. Ricardo
1Department of Medicine, University of Illinois, Chicago, Illinois
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Abstract

The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter, longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progression in the CRIC Study, grouped into the following six thematic categories: (1) sociodemographic and economic (sex, race/ethnicity, and nephrology care); (2) behavioral (healthy lifestyle, diet, and sleep); (3) genetic (apoL1, genome-wide association study, and renin-angiotensin-aldosterone system pathway genes); (4) cardiovascular (atrial fibrillation, hypertension, and vascular stiffness); (5) metabolic (fibroblast growth factor 23 and urinary oxalate); and (6) novel factors (AKI and biomarkers of kidney injury). Additionally, we highlight areas where future research is needed, and opportunities for interdisciplinary collaboration.

  • risk factors
  • chronic kidney disease
  • progression of chronic renal failure
  • Copyright © 2021 by the American Society of Nephrology
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Clinical Journal of the American Society of Nephrology: 16 (4)
Clinical Journal of the American Society of Nephrology
Vol. 16, Issue 4
April 07, 2021
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Risk Factors for CKD Progression
Mary Hannan, Sajid Ansari, Natalie Meza, Amanda H. Anderson, Anand Srivastava, Sushrut Waikar, Jeanne Charleston, Matthew R. Weir, Jonathan Taliercio, Edward Horwitz, Milda R. Saunders, Katherine Wolfrum, Harold I. Feldman, James P. Lash, Ana C. Ricardo, the CRIC Study Investigators
CJASN Apr 2021, 16 (4) 648-659; DOI: 10.2215/CJN.07830520

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Risk Factors for CKD Progression
Mary Hannan, Sajid Ansari, Natalie Meza, Amanda H. Anderson, Anand Srivastava, Sushrut Waikar, Jeanne Charleston, Matthew R. Weir, Jonathan Taliercio, Edward Horwitz, Milda R. Saunders, Katherine Wolfrum, Harold I. Feldman, James P. Lash, Ana C. Ricardo, the CRIC Study Investigators
CJASN Apr 2021, 16 (4) 648-659; DOI: 10.2215/CJN.07830520
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  • Article
    • Abstract
    • Introduction
    • Sociodemographic and Economic Factors
    • Behavioral Factors
    • Genetic Factors
    • Cardiovascular Factors
    • Metabolic Factors
    • Novel Factors
    • Contributions to Statistical Methodology for Cohort Studies of CKD
    • Clinical Implications and Limitations of CRIC Study Findings
    • Future Directions
    • Disclosures
    • Funding
    • Acknowledgments
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More in this TOC Section

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