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Genomics of Kidney Disease
Open Access

APOL1 Nephropathy: From Genetics to Clinical Applications

David J. Friedman and Martin R. Pollak
CJASN February 2021, 16 (2) 294-303; DOI: https://doi.org/10.2215/CJN.15161219
David J. Friedman
Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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Martin R. Pollak
Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
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Article Information

vol. 16 no. 2 294-303
DOI 
https://doi.org/10.2215/CJN.15161219
PubMed 
32616495

Published By 
American Society of Nephrology
Print ISSN 
1555-9041
Online ISSN 
1555-905X
History 
  • Published online February 8, 2021.

Article Versions

  • Earlier version (July 2, 2020 - 07:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by the American Society of Nephrology

Author Information

  1. David J. Friedman, and
  2. Martin R. Pollak
  1. Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
  1. Correspondence:
    Dr. David J. Friedman or Dr. Martin R. Pollak, Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215. Email: dfriedma{at}bidmc.harvard.edu or mpollak{at}bidmc.harvard.edu

Funding

  • National Center on Minority Health and Health Disparities

    NIHMD

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Article usage

Article usage: July 2020 to January 2021

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Jul 20209191416581
Aug 2020174621149
Sep 2020141599144
Oct 2020107628152
Nov 202095624149
Dec 202064578124
Jan 2021108712213
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Clinical Journal of the American Society of Nephrology: 16 (2)
Clinical Journal of the American Society of Nephrology
Vol. 16, Issue 2
February 08, 2021
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APOL1 Nephropathy: From Genetics to Clinical Applications
David J. Friedman, Martin R. Pollak
CJASN Feb 2021, 16 (2) 294-303; DOI: 10.2215/CJN.15161219

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APOL1 Nephropathy: From Genetics to Clinical Applications
David J. Friedman, Martin R. Pollak
CJASN Feb 2021, 16 (2) 294-303; DOI: 10.2215/CJN.15161219
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  • Article
    • Abstract
    • Introduction
    • APOL1 Biology: The Basics
    • APOL1 Nephropathy: One Gene, Many Diseases across the APOL1 Spectrum
    • APOL1 Risk Variants in Children
    • Global Burden of APOL1 Nephropathy
    • How Common Is APOL1-Associated Kidney Disease?
    • Transplantation: From Mechanism to Clinical Utility
    • Triggers of APOL1 Kidney Disease: Beyond Susceptibility
    • CKD and ESKD: When Is It APOL1 Nephropathy?
    • The Special Case of Diabetic Kidney Disease
    • Using APOL1 to Improve Hypertension and CKD Regimens
    • Therapeutic Approaches to APOL1 Kidney Disease
    • Disclosures
    • Funding
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

  • Inherited Kidney Complement Diseases
  • Clinical Integration of Genome Diagnostics for Congenital Anomalies of the Kidney and Urinary Tract
Show more Genomics of Kidney Disease

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Keywords

  • APOL1
  • chronic kidney disease
  • genetic kidney disease
  • Kidney Genomics Series
  • APOL1 protein
  • human
  • Apolipoprotein L1
  • HIV-Associated Nephropathy
  • African Americans
  • Glomerulosclerosis
  • Focal Segmental
  • kidney
  • hypertension
  • Genetics
  • Population
  • diabetes mellitus

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