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Klotho in Clinical Nephrology

Diagnostic and Therapeutic Implications

Javier A. Neyra, Ming Chang Hu and Orson W. Moe
CJASN January 2021, 16 (1) 162-176; DOI: https://doi.org/10.2215/CJN.02840320
Javier A. Neyra
1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas
2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
3Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky
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Ming Chang Hu
1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas
2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
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Orson W. Moe
1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas
2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
4Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas
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Article Information

vol. 16 no. 1 162-176
DOI 
https://doi.org/10.2215/CJN.02840320
PubMed 
32699047

Published By 
American Society of Nephrology
Print ISSN 
1555-9041
Online ISSN 
1555-905X
History 
  • Published online January 7, 2021.

Article Versions

  • Earlier version (July 22, 2020 - 10:03).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by the American Society of Nephrology

Author Information

  1. Javier A. Neyra1,2,3,
  2. Ming Chang Hu1,2,
  3. Orson W. Moe1,2,4
  1. 1Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas
  2. 2Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
  3. 3Division of Nephrology, Bone and Mineral Metabolism, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky
  4. 4Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas
  1. Correspondence:
    Dr. Javier A. Neyra or Dr. Ming Chang Hu, Charles and Jan Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856. Email: javier.neyra{at}uky.edu or ming-chang.hu{at}utsouthwestern.edu
View Abstract

Funding

  • National Institutes of Health

    R01-DK091392; R01-DK091392
  • Charles and Jane Pak Center Innovative Research Support

  • Endowed Professor Collaborative Research Support

  • George O’Brien Kidney Research Center

    P30-DK-07938
  • National Center for Advancing Translational Sciences

    UL1TR001998

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Article usage

Article usage: July 2020 to December 2020

AbstractFullPdf
Jul 20202684313239
Aug 20209196662
Sep 20205094259
Oct 20204962648
Nov 20203743827
Dec 20202963131
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Clinical Journal of the American Society of Nephrology: 16 (1)
Clinical Journal of the American Society of Nephrology
Vol. 16, Issue 1
January 07, 2021
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Klotho in Clinical Nephrology
Javier A. Neyra, Ming Chang Hu, Orson W. Moe
CJASN Jan 2021, 16 (1) 162-176; DOI: 10.2215/CJN.02840320

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Klotho in Clinical Nephrology
Javier A. Neyra, Ming Chang Hu, Orson W. Moe
CJASN Jan 2021, 16 (1) 162-176; DOI: 10.2215/CJN.02840320
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  • Article
    • Abstract
    • Introduction
    • Physiology of Klotho
    • Klotho in Disease States
    • Potential Mechanisms of Klotho-Mediated Kidney and Cardiovascular Protection
    • Biomarker Candidacy in Human Kidney Disease
    • Measurement of Soluble Klotho in Humans
    • Klotho-Focused Therapies
    • Summary and Call for Action
    • Disclosures
    • Funding
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

  • Decision Algorithm for Prescribing SGLT2 Inhibitors and GLP-1 Receptor Agonists for Diabetic Kidney Disease
  • Cuffless Blood Pressure Monitoring
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Keywords

  • Klotho;
  • nephrology;
  • kidney;
  • diagnosis;
  • therapy

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