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Research Letters
Open Access

COVID-19 in Peritoneal Dialysis Patients

Hua-Jun Jiang, Hui Tang, Fei Xiong, Wen-Li Chen, Jian-Bo Tian, Jing Sun, Jun-Wu Dong, Xiao-Hui Wang, Xiao-Fei Jin, Yan-Qiong Ding, Li Xu, Xiao-Ping Miao and Chun Zhang
CJASN January 2021, 16 (1) 121-123; DOI: https://doi.org/10.2215/CJN.07200520
Hua-Jun Jiang
1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Hui Tang
1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Fei Xiong
2Department of Nephrology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Wen-Li Chen
3Department of Nephrology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jian-Bo Tian
4Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jing Sun
1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jun-Wu Dong
5Department of Nephrology, Wuhan Fourth Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Xiao-Hui Wang
6Department of Nephrology, Wuhan No. 5 Hospital, Jianghan University, Wuhan, China
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Xiao-Fei Jin
7Department of Nephrology, People’s Hospital of Huang Pi, Wuhan, China
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Yan-Qiong Ding
2Department of Nephrology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Li Xu
3Department of Nephrology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Xiao-Ping Miao
4Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Chun Zhang
1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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    Table 1.

    Demographics and baseline characteristics of the study population

    CharacteristicsNon-Coronavirus Disease 2019, n=810Coronavirus Disease 2019, n=8
    Age, yr57 (47–67)55 (48–66)
    Sex, women, n (%)407 (50)6 (75)
    Current smoker, n (%)163 (20)0
    Body mass index, kg/m222.3 (20.3–24.2)23.0 (19.5–24.7)
    Primary cause of kidney failure, n (%)
     Diabetic kidney disease128 (16)2 (25)
     GN99 (12)3 (38)
     Hypertensive kidney disease279 (34)2 (25)
     Polycystic kidney disease5 (0.6)0
     Lupus nephritis9 (1)0
     Obstructive uropathy4 (0.5)1 (13)
    Coexisting diseases, n (%)
     Diabetes78 (10)2 (25)
     Hypertension235 (29)7 (88)
     Cardiovascular disease276 (34)7 (88)
     Respiratory disease19 (2)0
     Cancer5 (0.6)0
    Previous dialysis modality, n (%)
     CAPD723 (89)8 (100)
     APD9 (1)0
     DAPD29 (4)0
     Peritoneal dialysis + hemodialysis54 (7)0
    Total Kt/Vurea1.8 (1.5–2.3)1.6 (1.5–2.1)
    Ultrafiltration, ml/d626±365588±247
    Residual urine production, ml/d424±516250±207
    ACEI/ARB use, n (%)N/A7 (88)
    Symptoms, n (%)N/A
     Fever5 (63)
     Cough2 (25)
     Sputum production0 (0)
     Dyspnea2 (25)
     Fatigue4 (50)
    Radiologic findings, n (%)N/A
     Ground glass/patchy opacity7 (88)
     Fibrosis3 (38)
     Consolidation0 (0)
     Pulmonary nodule0 (0)
     Bilateral lesions7 (88)
    Laboratory findings, n (%)
     Leukocyte, /μl4880 (3560–6680)7130 (5120–1048)
     Platelet count, 103/μl189 (151–233)188 (155–228)
     Hemoglobin, g/dl10.1±2.28.8±2.4
     Neutrophil count, /μl4500 (3410–6080)6110 (3970–1045)
     Lymphocyte count, /μl1300 (1000–1670)730 (600–1030)
     Eosnophil count, /μl200 (120–330)60 (40–120)
     Serum albumin, g/dl3.6 (3.3–3.9)2.9 (2.5–3.6)
     ALT, U/L15 (10–20)18 (8–48)
     AST, U/L15 (11–21)24 (16–29)
     Serum creatinine, mg/dl9.98 (7.82–12.40)10.85 (8.68–12.73)
     Serum BUN, mg/dl50.4 (39.2–61.6)56.0 (36.4–70.0)
     Serum uric acid, mg/dl6.28 (5.21–7.32)7.19 (6.38–9.58)
     Fasting blood glucose, mg/dl82.8 (21.6–104.4)131.4 (111.6–144)
     C-reactive protein, ≥1 mg/dl73 (9)5 (7)
    Positive NATN/A7 (88)
    Positive antibody, n (%)N/A5
     IgM0
     IgG4 (80)
    Days from onset to antibody detection25 (20–34)
    Disease severity, severe, n (%)N/A2 (25)
    Treatment, n (%)N/A
     Antiviral agents6 (75)
     Antibacterial agents5 (63)
     Chloroquine phosphate1 (13)
     Glucocorticoids0 (0)
     Ig0 (0)
     Mechanical ventilation0 (0)
    Complications, n (%)N/A
     Acute hepatic injury4 (50)
     Acute cardiac injury2 (25)
     Heart failure4 (50)
     Cerebrovascular event1 (13)
     Peritonitis1 (13)
     Hypokalemia4 (50)
     Hypocalcemia2 (25)
     ARDS0 (0)
    Outcome, n (%)N/A
     Recovered6 (75)
     Deceased2 (25)
    • Continuous variables were described as median and interquartile range or mean and SD, and differences were assessed using analysis of t test or Mann–Whitney U test. Categorical variables were expressed as number (percentage), and differences between groups were assessed using the Fisher exact test. ARDS was defined according to the Berlin definition. Acute cardiac injury was diagnosed if the serum levels of cardiac biomarkers (e.g., troponin I) were above the 99th percentile upper reference limit or new abnormalities were shown in electrocardiography and echocardiography. Acute hepatic injury was defined as an elevation in AST or ALT of >15 times the upper limit of normal. CAPD, continuous ambulatory peritoneal dialysis; APD, automated peritoneal dialysis; DAPD, daytime ambulatory peritoneal dialysis; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; N/A, not available; ALT, alanine aminotransferase; AST, aspartate aminotransferase; NAT, nucleic acid testing; ARDS, acute respiratory distress syndrome.

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Clinical Journal of the American Society of Nephrology: 16 (1)
Clinical Journal of the American Society of Nephrology
Vol. 16, Issue 1
January 07, 2021
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COVID-19 in Peritoneal Dialysis Patients
Hua-Jun Jiang, Hui Tang, Fei Xiong, Wen-Li Chen, Jian-Bo Tian, Jing Sun, Jun-Wu Dong, Xiao-Hui Wang, Xiao-Fei Jin, Yan-Qiong Ding, Li Xu, Xiao-Ping Miao, Chun Zhang
CJASN Jan 2021, 16 (1) 121-123; DOI: 10.2215/CJN.07200520

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COVID-19 in Peritoneal Dialysis Patients
Hua-Jun Jiang, Hui Tang, Fei Xiong, Wen-Li Chen, Jian-Bo Tian, Jing Sun, Jun-Wu Dong, Xiao-Hui Wang, Xiao-Fei Jin, Yan-Qiong Ding, Li Xu, Xiao-Ping Miao, Chun Zhang
CJASN Jan 2021, 16 (1) 121-123; DOI: 10.2215/CJN.07200520
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