Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow CJASN on Twitter
  • CJASN RSS
  • Community Forum
Original ArticlesChronic Kidney Disease
You have accessRestricted Access

Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD

Matthew F. Blum, Aditya Surapaneni, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Eric A. Whitsel, Melinda C. Power and Morgan E. Grams
CJASN March 2020, 15 (3) 311-319; DOI: https://doi.org/10.2215/CJN.08350719
Matthew F. Blum
1Department of Medicine, School of Medicine, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Matthew F. Blum
Aditya Surapaneni
2Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James D. Stewart
3Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Duanping Liao
4Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeff D. Yanosky
4Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric A. Whitsel
3Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;
5Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Melinda C. Power
6Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Morgan E. Grams
2Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland;
7Division of Nephrology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Visual Abstract

Figure1
  • Download figure
  • Open in new tab
  • Download powerpoint

Abstract

Background and objectives Exposure to particulate matter (PM) <2.5 μm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD.

Design, setting, participants, & measurements The study included 10,997 participants from the Atherosclerosis Risk in Communities cohort who were followed from 1996–1998 through 2016. Monthly mean PM2.5 concentrations (μg/m3) were estimated at geocoded participant addresses using geographic information system–based, spatiotemporal generalized additive mixed models—including geospatial covariates such as land use—and then averaged over the 12-month period preceding participant examination. Covariate-adjusted, cross-sectional associations of PM2.5, baseline eGFR, and urinary albumin-creatinine ratio (UACR) were estimated using linear regression. PM2.5 and incident CKD (defined as follow-up eGFR <60 ml/min per 1.73 m2 with ≥25% eGFR decline relative to baseline, CKD-related hospitalization or death based on International Classification of Diseases 9/10 codes, or development of ESKD) associations were estimated using Cox proportional hazards regression. Modeling was stratified by study site, and stratum-specific estimates were combined using random-effects meta-analyses.

Results Baseline mean participant age was 63 (±6) years and eGFR was 86 (±16) ml/min per 1.73 m2. There was no significant PM2.5-eGFR association at baseline. Each 1-μg/m3 higher annual average PM2.5 was associated with higher UACR after adjusting for demographics, socioeconomic status, and clinical covariates (percentage difference, 6.6%; 95% confidence interval [95% CI], 2.6% to 10.7%). Each 1-μg/m3 higher annual average PM2.5 was associated with a significantly higher risk of incident CKD (hazard ratio, 1.05; 95% CI, 1.01 to 1.10).

Conclusions Exposure to higher annual average PM2.5 concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.

  • chronic kidney disease
  • albuminuria
  • glomerular filtration rate
  • epidemiology and outcomes
  • ARIC
  • particulate matter
  • air pollution
  • humans
  • cross-sectional studies
  • creatinine
  • linear models
  • geographic information systems
  • International Classification of Diseases
  • follow-up studies
  • confidence intervals
  • chronic renal insufficiency
  • chronic kidney failure
  • kidney function tests
  • cohort studies
  • atherosclerosis
  • demography
  • hospitalization
  • social class
  • albumin
  • Received July 18, 2019.
  • Accepted January 21, 2020.
  • Copyright © 2020 by the American Society of Nephrology
View Full Text

If you do not have an account on CJASN or JASN, you will need to create one.  See the instructions below for details on how to create an account. 

Log in using your username and password

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.

Purchase access

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$32.00

You will have access to the article for 24 hours.  

When you create an account, you will be asked for your name, email address and other information.  Just like commercial web sites, we do need details from you in order to complete your purchase of an article.  Select the "Create an Account" link to create your account. 

You will then be asked to register a user name, email address and you will need to create a password that is at least eight characters in length. As you move through the registration page, you will have to verify you are a person by completing a Captcha request.   Lastly, your first and last name will be required. 

Once your information is successfully saved, the system will redisplay the home page of the journal.  From there, navigate back to the article to purchase.  Select the article and at the bottom of the page, use the credentials you just created to login. The article will be added to your shopping cart.  You can continue to navigate across JASN and CJASN adding to your cart from both journals. When you are ready to complete your purchse, select the Shopping Cart from the upper right hand corner of the page and follow the onscreen instructions. 

PreviousNext
Back to top

In this issue

Clinical Journal of the American Society of Nephrology: 15 (3)
Clinical Journal of the American Society of Nephrology
Vol. 15, Issue 3
March 06, 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in CJASN.
Enter multiple addresses on separate lines or separate them with commas.
Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD
Matthew F. Blum, Aditya Surapaneni, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Eric A. Whitsel, Melinda C. Power, Morgan E. Grams
CJASN Mar 2020, 15 (3) 311-319; DOI: 10.2215/CJN.08350719

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD
Matthew F. Blum, Aditya Surapaneni, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Eric A. Whitsel, Melinda C. Power, Morgan E. Grams
CJASN Mar 2020, 15 (3) 311-319; DOI: 10.2215/CJN.08350719
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosures
    • Funding
    • Supplemental Material
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

Original Articles

  • Acute Kidney Injury among Black Patients with Sickle Cell Trait and Sickle Cell Disease
  • Acute Kidney Injury, Microvascular Rarefaction, and Estimated Glomerular Filtration Rate in Kidney Transplant Recipients
  • The Association of Time to Organ Procurement on Short- and Long-Term Outcomes in Kidney Transplantation
Show more Original Articles

Chronic Kidney Disease

  • NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD
  • Effect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes
  • Combination Treatment with Sodium Nitrite and Isoquercetin on Endothelial Dysfunction among Patients with CKD
Show more Chronic Kidney Disease

Cited By...

  • Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China
  • Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis
  • Air Pollution and Kidney Disease
  • Google Scholar

Similar Articles

Related Articles

  • Air Pollution and Kidney Disease
  • PubMed
  • Google Scholar

Keywords

  • chronic kidney disease
  • albuminuria
  • glomerular filtration rate
  • epidemiology and outcomes
  • ARIC
  • particulate matter
  • air pollution
  • humans
  • Cross-Sectional Studies
  • creatinine
  • linear models
  • geographic information systems
  • International Classification of Diseases
  • follow-up studies
  • confidence intervals
  • chronic renal insufficiency
  • chronic kidney failure
  • Kidney Function Tests
  • cohort studies
  • Atherosclerosis
  • Demography
  • hospitalization
  • Social Class
  • albumin

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Trainee of the Year
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • CJASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About CJASN
  • CJASN Email Alerts
  • CJASN Key Impact Information
  • CJASN Podcasts
  • CJASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe

© 2021 American Society of Nephrology

Print ISSN - 1555-9041 Online ISSN - 1555-905X

Powered by HighWire