Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow CJASN on Twitter
  • CJASN RSS
  • Community Forum
Review
You have accessRestricted Access

Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation

Amanda DeMauro Renaghan, Edgar A. Jaimes, Jolanta Malyszko, Mark A. Perazella, Ben Sprangers and Mitchell Howard Rosner
CJASN February 2020, 15 (2) 289-297; DOI: https://doi.org/10.2215/CJN.08580719
Amanda DeMauro Renaghan
1Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Edgar A. Jaimes
2Department of Medicine, Renal Service, Memorial Sloan Kettering Cancer Center, New York, New York;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jolanta Malyszko
3Department of Nephrology, Dialysis and Internal Medicine, Warsaw Medical University, Warsaw, Poland;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark A. Perazella
4Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut;
5Veterans Affairs Medical Center, West Haven, Connecticut;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ben Sprangers
6Department of Microbiology and Immunology, Laboratory of Molecular Immunology, Rega Institute, KU Leuven, Belgium; and
7Division of Nephrology, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mitchell Howard Rosner
1Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data Supps
  • Info & Metrics
  • View PDF
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Hematopoietic stem cell transplantation is a life-saving therapy for many patients with cancer, as well as patients with some nonmalignant hematologic disorders, such as aplastic anemia, sickle cell disease, and certain congenital immune deficiencies. Kidney injury directly associated with stem cell transplantation includes a wide range of structural and functional abnormalities, which may be vascular (hypertension, thrombotic microangiopathy), glomerular (albuminuria, nephrotic glomerulopathies), and/or tubulointerstitial. AKI occurs commonly after stem cell transplant, affecting 10%–73% of patients. The cause is often multifactorial and can include sepsis, nephrotoxic medications, marrow infusion syndrome, hepatic sinusoidal obstruction syndrome, thrombotic microangiopathy, infections, and graft versus host disease. The risk of post-transplant kidney injury varies depending on patient characteristics, type of transplant (allogeneic versus autologous), and choice of chemotherapeutic conditioning regimen (myeloablative versus nonmyeloablative). Importantly, AKI is associated with substantial morbidity, including the need for KRT in approximately 5% of patients and the development of CKD in up to 60% of transplant recipients. AKI has been associated universally with higher all-cause and nonrelapse mortality regardless of transplant type, and studies have consistently shown extremely high (>80%) mortality rates in those patients requiring acute dialysis. Accordingly, prevention, early recognition, and prompt treatment of kidney injury are essential to improving kidney and patient outcomes after hematopoietic stem cell transplantation, and for realizing the full potential of this therapy.

  • acute renal failure
  • chronic kidney disease
  • stem cell
  • oncology
  • humans
  • graft versus host disease
  • albuminuria
  • hepatic veno-occlusive disease
  • transplant recipients
  • bone marrow
  • renal dialysis
  • transplantation conditioning
  • acute kidney injury
  • hematopoietic stem cell transplantation
  • kidney
  • chronic renal insufficiency
  • thrombotic microangiopathies
  • aplastic anemia
  • sepsis
  • sickle cell anemia
  • hypertension
  • neoplasms
  • Copyright © 2020 by the American Society of Nephrology
View Full Text

If you do not have an account on CJASN or JASN, you will need to create one.  See the instructions below for details on how to create an account. 

Log in using your username and password

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.

Purchase access

You will have access to the article for 24 hours.  

When you create an account, you will be asked for your name, email address and other information.  Just like commercial web sites, we do need details from you in order to complete your purchase of an article.  Select the "Create an Account" link to create your account. 

You will then be asked to register a user name, email address and you will need to create a password that is at least eight characters in length. As you move through the registration page, you will have to verify you are a person by completing a Captcha request.   Lastly, your first and last name will be required. 

Once your information is successfully saved, the system will redisplay the home page of the journal.  From there, navigate back to the article to purchase.  Select the article and at the bottom of the page, use the credentials you just created to login. The article will be added to your shopping cart.  You can continue to navigate across JASN and CJASN adding to your cart from both journals. When you are ready to complete your purchse, select the Shopping Cart from the upper right hand corner of the page and follow the onscreen instructions. 

PreviousNext
Back to top

In this issue

Clinical Journal of the American Society of Nephrology: 15 (2)
Clinical Journal of the American Society of Nephrology
Vol. 15, Issue 2
February 07, 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
View Selected Citations (0)
Print
Download PDF
Sign up for Alerts
Email Article
Thank you for your help in sharing the high-quality science in CJASN.
Enter multiple addresses on separate lines or separate them with commas.
Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation
(Your Name) has sent you a message from American Society of Nephrology
(Your Name) thought you would like to see the American Society of Nephrology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation
Amanda DeMauro Renaghan, Edgar A. Jaimes, Jolanta Malyszko, Mark A. Perazella, Ben Sprangers, Mitchell Howard Rosner
CJASN Feb 2020, 15 (2) 289-297; DOI: 10.2215/CJN.08580719

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Acute Kidney Injury and CKD Associated with Hematopoietic Stem Cell Transplantation
Amanda DeMauro Renaghan, Edgar A. Jaimes, Jolanta Malyszko, Mark A. Perazella, Ben Sprangers, Mitchell Howard Rosner
CJASN Feb 2020, 15 (2) 289-297; DOI: 10.2215/CJN.08580719
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Introduction
    • Epidemiology of AKI
    • Pathophysiology of AKI
    • Biomarkers for the Diagnosis of AKI
    • Prevention and Treatment of AKI
    • CKD and Hematopoietic Stem Cell Transplantation
    • Conclusions
    • Disclosures
    • Funding
    • Footnotes
    • References
  • Figures & Data Supps
  • Info & Metrics
  • View PDF

More in this TOC Section

  • Klotho in Clinical Nephrology
  • Decision Algorithm for Prescribing SGLT2 Inhibitors and GLP-1 Receptor Agonists for Diabetic Kidney Disease
  • Cuffless Blood Pressure Monitoring
Show more Review

Cited By...

  • No citing articles found.
  • Google Scholar

Similar Articles

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Keywords

  • acute renal failure
  • chronic kidney disease
  • stem cell
  • oncology
  • Humans
  • Graft versus Host Disease
  • albuminuria
  • hepatic veno-occlusive disease
  • Transplant Recipients
  • Bone Marrow
  • renal dialysis
  • transplantation conditioning
  • acute kidney injury
  • Hematopoietic Stem Cell Transplantation
  • kidney
  • chronic renal insufficiency
  • Thrombotic Microangiopathies
  • aplastic anemia
  • sepsis
  • sickle cell anemia
  • hypertension
  • Neoplasms

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Trainee of the Year
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • CJASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About CJASN
  • CJASN Email Alerts
  • CJASN Key Impact Information
  • CJASN Podcasts
  • CJASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe

© 2021 American Society of Nephrology

Print ISSN - 1555-9041 Online ISSN - 1555-905X

Powered by HighWire