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Original ArticlesGeriatric Nephrology
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Perspectives of Older Kidney Transplant Recipients on Kidney Transplantation

Jule Pinter, Camilla S. Hanson, Jeremy R. Chapman, Germaine Wong, Jonathan C. Craig, Jane O. Schell and Allison Tong
CJASN March 2017, 12 (3) 443-453; DOI: https://doi.org/10.2215/CJN.05890616
Jule Pinter
*Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia;
†Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia;
‡Department of Medicine, Division of Nephrology, Würzburg University Clinic, Würzburg, Germany;
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Camilla S. Hanson
*Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia;
†Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia;
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Jeremy R. Chapman
§Centre for Transplant and Renal Research, Westmead Hospital, Westmead, New South Wales, Australia; and
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Germaine Wong
*Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia;
†Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia;
§Centre for Transplant and Renal Research, Westmead Hospital, Westmead, New South Wales, Australia; and
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Jonathan C. Craig
*Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia;
†Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia;
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Jane O. Schell
║Section of Palliative Care and Medical Ethics, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania
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Allison Tong
*Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia;
†Centre for Kidney Research, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia;
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Abstract

Background and objectives Older kidney transplant recipients are susceptible to cognitive impairment, frailty, comorbidities, immunosuppression-related complications, and chronic graft failure, however, there has been limited focus on their concerns and expectations related to transplantation. This study aims to describe the perspectives of older kidney transplant recipients about their experience of kidney transplantation, self-management, and treatment goals to inform strategies and interventions that address their specific needs.

Design, setting, participants, & measurements Face-to-face semistructured interviews were conducted with 30 kidney transplant recipients aged 65–80 years from five renal units in Australia. Transcripts were analyzed thematically.

Results Six themes were identified: restoring vitality of youth (with subthemes of revived mindset for resilience, embracing enjoyment in life, drive for self-actualization); persisting through prolonged recovery (yielding to aging, accepting functional limitations, pushing the limit, enduring treatment responsibilities); imposing sicknesses (combatting devastating comorbidities, painful restrictions, emerging disillusionment, anxieties about accumulating side effects, consuming treatment burden); prioritizing graft survival (privileged with a miracle, negotiating risks for longevity, enacting a moral duty, preserving the last opportunity); confronting health deterioration (vulnerability and helplessness, narrowing focus to immediate concerns, uncertainty of survival); and value of existence (purpose through autonomy, refusing the burden of futile treatment, staying alive by all means).

Conclusions Older kidney transplant recipients felt able to enjoy life and strived to live at their newly re-established potential and capability, which motivated them to protect their graft. However, some felt constrained by slow recuperation and overwhelmed by unexpected comorbidities, medication-related side effects, and health decline. Our findings suggest the need to prepare and support older recipients for self-management responsibilities, clarify their expectations of post-transplant risks and outcomes, and provide assistance through prolonged recovery after kidney transplantation.

  • geriatric nephrology
  • quality of life
  • transplant outcomes
  • adolescent
  • aging
  • anxiety
  • Australia
  • cognition disorders
  • comorbidity
  • goals
  • graft survival
  • humans
  • immunosuppression
  • kidney transplantation
  • longevity
  • medical futility
  • moral obligations
  • motivation
  • negotiating
  • self-care
  • transplant recipients
  • uncertainty

Introduction

Kidney transplantation can confer survival and quality-of-life benefits compared with dialysis in older kidney transplant recipients (1–7), however, the effect of aging on post-transplant management is acknowledged as a considerable challenge (8–10). The number of prevalent older kidney transplant recipients is expected to grow due to improved graft and survival outcomes through to older age, and the last decade has seen a three-fold increase in the number of transplants in older adults above the age of 65 years in the United States (11,12). Physical and cognitive impairment, chronic comorbidities, and complications associated with immunosuppression may prolong postsurgical recovery (13–23), add complexity to post-transplant care, and impair capacity for self-management.

Older kidney transplant recipients value the survival gained by transplant, however, they also struggle with persistent limitations after transplant, the side effects of immunosuppressive medication, and worry about a possible return to dialysis should the transplant fail (24). Little is known about their expectations of kidney transplantation, how they cope with self-management responsibilities, and how they perceive their prognosis post-transplant. This study aims to describe the range and depth of the experiences and perspectives of older kidney transplant recipients about their expectations, self-management, and treatment goals while living and aging with a kidney transplant. A broad understanding may inform education, strategies, and interventions for improving transplant outcomes in older patients.

Materials and Methods

Study reporting is based on the Consolidated Criteria for Reporting Qualitative Health Research (25).

Participant Selection and Setting

Participants were eligible if they were kidney transplant recipients, aged 65 years and over, and English speaking. We used purposive sampling to obtain a maximum variation of demographics (age, sex) and clinical characteristics (including time since transplant, complications). The participants were recruited from Westmead Hospital in Sydney (Australia) and five referral dialysis units, which provide follow-up after transplant. Ethics approval was obtained from the Western Sydney Local Health District. All participants provided informed consent for study participation.

Data Collection

We developed an interview guide informed by a systematic review of older kidney transplant recipient perspectives on kidney transplantation (24) (Supplemental Table 1). A.T./J.P. conducted face-to-face semistructured interviews from April to June 2015 until data saturation, i.e., no new concepts were obtained. All interviews were audio-recorded and transcribed verbatim.

Data Analysis

Using thematic analysis, J.P. read each transcript line-by-line, then conceptualized and coded by hand all meaningful segments of text into concepts inductively identified from the data. Similar concepts were grouped into preliminary themes and subthemes. C.S.H. and A.T. read the transcripts independently and discussed the preliminary coding structure to enhance the analytic framework, and to ensure that it captured the full breadth and depth of data collected. The transcripts were imported into HyperRESEARCH (Version 2.8.3; ResearchWare Inc.). The software was used to generate a report of all of the themes and qualitative data coded to each theme. J.P., C.S.H., and A.T. identified and discussed conceptual patterns among the themes, which were mapped into a schema (Figure 1).

Figure 1.
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Figure 1.

Thematic schema of the perspectives of older kidney transplant recipients. Kidney transplantation restores vitality and autonomy for older kidney transplant recipients, which enables them to enjoy life, and strive to fulfill their now attainable goals. They prioritize the functioning of their graft, as they feel grateful, privileged, and responsible to preserve what could be their final chance of recuperation. However, “persisting through prolonged recovery,” and “imposing sicknesses” challenge the regained vitality. Some participants may experience the consequences of health decline. If they confront deterioration in health, older kidney transplant recipients may feel vulnerable and uncertain of their survival. This can lead some to question the value of their own existence.

Results

Of the 33 invited to participate, 30 (91%) were interviewed. Nonparticipation was due to refusal or sickness. The participant characteristics are shown in Tables 1 and 2. Participants were aged from 65 to 80 years (mean 70.1 years). Fifteen (50%) spoke English as their second language. The age they received their current transplant ranged from 50 to 71 years (mean 64.0 years), with the total duration since transplantation ranging from 0.5 to 25 years (mean 6.4 years). Four (13%) had received a transplant within the past 1 year. Fifteen (50%) were men, and 21 (70%) had a deceased donor kidney transplant. One participant had undergone a prior transplant. The average duration of the interview was 40 minutes and all participants were interviewed at their homes.

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Table 1.

Participant demographic characteristics (n=30)

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Table 2.

Participant clinical characteristics (n=30)

Six themes were identified: restoring vitality of youth; persisting through prolonged recovery; imposing sicknesses; prioritizing graft survival; confronting health deterioration; and value of existence. The themes and respective subthemes are described in the following section and a selection of quotations for each subtheme is provided in Table 3. The patterns and relationships among themes are depicted in the thematic schema (Figure 1).

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Table 3.

Illustrative quotations to reflect themes on older kidney transplant recipients’ perspectives on kidney transplantation

Restoring Vitality of Youth

Revived Mindset for Resilience.

The kidney transplant “made a huge difference” and some claimed to feel “the best for 20 years.” Some felt “young” and revived with a sense of hope, reassurance, and confidence in their own capacity to overcome sicknesses and persist through setbacks. One participant believed that his mood and energy level was restored to that of an 18-year-old.

Embracing Enjoyment in Life.

Some felt energized by the mental and physical improvements after transplant. The transplant enabled them to live “in the moment now, enjoying life.” Others felt that “the whole world opened up.” Reversal of dietary and travel restrictions and being able “to just do what I want to do” provided enormous relief and the ability to live some “nice, easy remaining years of life.”

Drive for Self-Actualization.

Having a new lease on life, some participants suddenly had “all the future ahead” and gained confidence to achieve their potential. With transplant, they were given time, which they consciously utilized until “every moment was taken up to make up for the lost time on dialysis,” and immersed themselves in their work and hobbies.

Persisting through Prolonged Recovery

Yielding to Aging.

Some were conscious of their older age and believed that they would need a prolonged time of recuperation after transplant compared with younger transplant recipients. Some felt prone to experience more difficulties in recovery and health due to their “age factor.”

Accepting Functional Limitations.

After transplant, some felt frustrated when they continued to experience limitations in their mobility. They were unable to walk and exercise as they could not keep physically fit, and became fearful of sustaining injuries from falling. Some noted a marked deterioration in their physical abilities after transplant—“My feet are numb and have deformed from the diabetes. I’m a bit unstable in my walking and it has been getting worse since transplant.” Some believed that their physicians instructed “impossible” levels of physical activity after transplant such as walking for an hour, and felt exasperated. Some accepted their limitations and recalibrated their expectations to physical activity levels for which they were capable.

Pushing the Limit.

Encouraged by health care providers “to push themselves,” some were determined to overcome their bodily constraints. They persevered and challenged themselves despite feeling that “your brain wants to, but your body doesn’t help you to.” Some strived to the point of physical exhaustion and “pushed the limit intentionally too hard” until they “got physically so run down.”

Enduring Treatment Responsibilities.

Some participants felt unprepared for the ongoing self-management responsibilities, particularly with regards to attending follow-up appointments, navigating multispecialty services, and taking a complex regimen of immunosuppression medications—“I didn’t know that there is so much work involved, you’ve got to visit doctors and things like that.”

Imposing Sicknesses

Combatting Devastating Comorbidities.

For some, the well being gained through transplant was devastated by the diagnosis and treatment consequences of other serious comorbidities, such as bowel cancer that involved extensive abdominal surgery or chemotherapy.

Painful Restrictions.

Some participants experienced episodes of agonizing and persistent pain that restricted their mobility. Others felt distressed by stabbing facial sensations induced by the herpes zoster virus. Yet, some preferred to endure the pain and were determined to avoid analgesics as they feared it would potentially damage the graft or trigger distressful side effects, such as hallucinations.

Emerging Disillusionment.

Some were disappointed when the transplant did not meet their expectations of rapid and easy recovery with improved quality of life. Some believed that transplant would be a permanent cure and reverse their kidney disease “I thought the problem (of kidney disease) had fixed.” Thus, they felt inadequately prepared mentally to manage and cope with unexpected complications such as diabetes “I wasn’t going to go cranky at the doctor for not telling me. It’s just part and parcel of what happens. They should tell you because it’s a risk. Diabetes isn’t a joke. The transplant’s ok, that’s kind of over. But now the diabetes is bothering me.”

Anxieties about Accumulating Side Effects.

Some participants felt anxious that “taking heaps and heaps of tablets” could “shorten your life span” or trigger cumulative drug resistance. One woman was concerned of the increased risk of cancer. Some felt distressed if they experienced uncontrollable side effects such as severe weight loss secondary to diarrhea or fungal oral infections. Others fought against prednisone-induced hunger by eating less yes still gained weight “You’re damned if you do and you’re damned if you don’t.”

Consuming Treatment Burden.

Participants felt increasingly weary when the treatment of transplant-related complications coincided and interfered with treatment of their other comorbidities. One recipient believed that “running from one doctor to another (was) very hard for an older person.” For some, the “rocky road” of unpreventable and accumulating health “problems” led to regret where some questioned whether transplant had been the right decision.

Prioritizing Graft Survival

Privileged with a Miracle.

Transplant was described as a “gift” and a “miracle,” particularly as some had not expected to receive a transplant due to their older age. Their long-standing suffering on dialysis enabled some to appreciate the opportunity of transplant—“If people were thinking about having a transplant or staying on dialysis, I would tell them every time, go for the transplant, because it worked out beautifully for me.”

Negotiating Risks for Longevity.

Motivated to avoid dialysis, some willingly accepted the risks of immunosuppression for longevity. Those who were concerned about immunosuppressive side effects were challenged to overcome their anxieties and focus on enjoying the gift of a functioning graft.

Enacting a Moral Duty.

Some believed that they owed a “massive responsibility” to their donor to protect and maximize graft survival. “Wasting a perfectly good kidney” by not looking after oneself was deemed morally wrong, “idiotic and stupid” and an act of “abuse.”

Preserving the Last Opportunity.

Some were certain that their current transplant was their “last and only chance” and doubted that they would be eligible for another transplant due to their older age. Some thought that people aged 60–70 years would be precluded from transplantation. This motivated and sustained their efforts to preserve their current graft, such as adhering to their medication regimen, and making healthy lifestyle choices regarding diet and exercise.

Confronting Health Deterioration

Vulnerability and Helplessness.

A decline of health, imposed by other sicknesses or severe complications after transplant, caused emotional turmoil and uncertainty for some. This intensified their sense of vulnerability and helplessness, which some internalized. Some felt unable to continuously exercise self-management without the indispensable practical support from their partners. This was particularly challenging for participants whose partner had died.

Narrowing Focus to Immediate Concerns.

If their health deteriorated, some participants refused to be constantly reminded of their sicknesses, as they felt unable to cope. They abandoned long-term goals such as planning for vacation to avoid disappointment, and focused their attention to immediate day-to-day tasks.

Uncertainty of Survival.

Increasing hospitalization led to loss of hope—“They (physicians) can’t fix it”; and uncertainty about death and potential graft loss—“will I make it this time?” and “how long am I going to last with this kidney?” Some identified a health care power of attorney and made treatment decisions for the future while they still had autonomous capacity to do so. Others preferred not to dwell prematurely on end-of-life decisions.

Value of Existence

Purpose through Autonomy.

Some feared the unmanageable consequences of increasing physical immobility, and felt that confinement to bed, losing mobility, and having to depend on others, would rob their sense of purpose such that “life wouldn’t be worth living” anymore. Transplant had restored their independence and freedom, and the loss of such would diminish the value in having a transplant.

Refusing the Burden of Futile Treatment.

Some were unwilling to return to dialysis should the transplant fail. Some felt they had merely existed, deprived of any self- or life-value while on dialysis. Some chose to remove their fistula, or opted against all forms of life-sustaining therapies. Others described the difficulties of coping with sicknesses and would refuse curative therapy, such as chemotherapy for cancers, even if it meant risking graft loss. Further, some felt unable to discuss their concerns or decisions with others, including their nephrologist or other family members whom they did not want to cause concern.

Staying Alive by All Means.

In contrast, other participants prioritized survival to be of highest importance and viewed returning to dialysis to be the only available and valid option as they had “no wish to die at this stage.”

Discussion

Our study highlights the range and heterogeneity of experiences among older kidney transplant recipients, from being able to enjoy the extensive quality-of-life benefits of a transplant, to remaining constrained by functional limitations, or suffering from comorbidities or general health decline. Older kidney transplant recipients felt physically and mentally revived after kidney transplantation, and used their restored energy and autonomy to enjoy life and fulfill their new ambitious, but now attainable, goals. The current transplant was their last hope, which motivated their efforts to preserve graft function and manage their health. Age-related and functional limitations impeded rapid recovery yet some persisted by pushing their limit of physical activity. Some felt inadequately prepared for the multiple treatment responsibilities after transplantation and became disillusioned and devastated when they experienced severe and often unexpected complications, debilitating pain that impaired normal functioning, and accumulating side effects of medications that increased the burden of treatment and diminished the health that transplantation had restored.

Some older kidney transplant recipients were acutely aware of how their older age could prolong and complicate recovery. Others struggled to meet their physician’s recommended level of physical activity during post-transplant recovery due to pain, and functional impairment. A recent systematic review suggested that older transplant recipients regain strength and vitality, while they struggle with residual functional limitations (24). Some studies, albeit limited, suggest that the functional status of older kidney transplant recipients is an independent predictor of post-transplant survival (13,14,26,27). Older kidney transplant recipients with the lowest physical function scores pretransplantation have the highest mortality rates after transplantation compared with younger recipients (13,14). A study found that more than half of older kidney transplant recipients reported being disabled or required assistance for at least one daily-living activity, with housekeeping, grocery shopping, and laundry being the activities most commonly affected, and a fifth recalled having fallen more than once in the past year (28). A regular assessment of functional impairment and frailty (14), the provision of exercise training and physiotherapy (29) to prevent falls, as well as additional assistance with mobility restrictions such as walking aids, and arranged transport to and from health care facilities may sustain and foster the patient’s functional capacity after transplant.

Our findings have implications for education, communication, and advance care planning. We suggest that older kidney transplant candidates may have unique information needs compared with younger patients, as they may be more vulnerable to adverse effects of comorbidities, health decline, and limitations due to the aging process, and experience higher rates of hospitalization and skilled nursing facility care placements (30,31). Older recipients identified the need for specific advice regarding physical activity and exercise that considers their degree of functional limitations, and promotes achievable fitness goals. They wanted to be informed about the potential risk of unexpected complications, such as diabetes, the cumulative side effects of medication, and fears regarding pain management. They depended on others to attend follow-up appointments, and had to coordinate and navigate multispecialty services. Information about identifying pragmatic support for post-transplant follow-up appears critical to help older transplant recipients better self-manage, and coordinate their care post-transplantation. This may also include discussion about the increased risk of hospitalization and complications in older recipients. We suggest that transplant centers provide at least initial education addressing these specific transplant-related needs, which could subsequently be followed up by primary care providers (e.g., with geriatricians). Further studies may be needed to identify optimal strategies for delivering this information in clinical settings.

Our findings provide broad insights on the expectations and the existential angst related to aging, comorbidities, medication, and fear of losing the graft. Some older kidney transplant recipients felt disappointed when the transplant did not meet their expectation of rapid recovery. Others believed that transplant would be a permanent cure and reverse their kidney disease. As such, some felt inadequately prepared to continuously manage multiple treatment responsibilities after transplantation, and to cope with unexpected adverse complications. This highlights the need to clarify and ensure realistic expectations of recovery. Given the range and differences of experiences, we would suggest utilizing effective communication strategies in an individualized patient-centered approach to identify their specific priorities and concerns, and address their specific needs. Motivational interviewing techniques (32,33) and communication frameworks such as “SPIKES” (Setting, Perception, Invitation, Knowledge, Emotions, Summary) (34,35) have been developed to identify the patient’s concerns, and respond to informational and emotional concerns. An ongoing dialogue facilitated by patient-reported symptom measures and effective communication structures can inform decisions about managing side effects (36,37), define achievable goals for the period of recovery (38), and build rapport and trust, which may temper disillusionment if adverse side effects or complications occur. Proposed strategies for clinical practice derived from our findings are outlined in Table 4.

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Table 4.

Proposed strategies for clinical practice

Some older transplant recipients decided they would not return to dialysis should their graft fail and elected to remove their fistula. Some felt uncertain about their prognosis and those who had debilitating and unexpected complications questioned whether transplant had been the right decision. Importantly, some recipients in our study had not explicitly discussed their decisions with anyone, as they were reluctant to burden others by expressing their treatment preference for conservative (nondialytic) management. We suggest to implement advance care planning at appropriate times, e.g., during hospitalization or deterioration of health, to prepare patients and their family/caregiver for future treatment decision-making (39).

In our study, we included prevalent older kidney transplant recipients with a broad range of demographics and comorbidities. However, there are some potential limitations. Older recipients were interviewed once and our data may not capture subsequent changes in perspectives. Older recipients were recruited from one major transplant center in Australia, which may limit the transferability of findings, although similar findings in the systematic review of qualitative studies of older transplant recipient perspectives suggest that the results may be relevant to other contexts (24). Critically ill patients were excluded for ethical reasons, and thus concerns or priorities specific to them, such as end-of-life care, could not be explored. We interviewed patients with a functioning transplant, and the effect of transplant failure on the perspectives of older patients who returned to dialysis could be explicitly addressed in future research.

In conclusion, kidney transplantation can restore vigor and vitality for older kidney transplant recipients, but some may feel constrained by slow and complicated recuperation, and overwhelmed by treatment burden due to comorbidities, side effects of drugs, and deteriorating health and mobility. Providing support through prolonged recovery, sustaining the patient’s functional capacity, addressing treatable side effects, and eliciting the recipient’s perception of prognosis, goals, and values, may improve satisfaction and empower older recipients to preserve what they perceive as their last opportunity for transplant.

Disclosures

None.

Acknowledgments

We sincerely thank all of the participants for taking the time to share their perspectives. We would like to thank Christoph Wanner for his valuable contribution in providing feedback on the manuscript.

This study was funded by Australian Research Council Grant DE120101710. A.T. is supported by National Health and Medical Research Council Fellowship ID 1106716.

The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript.

Footnotes

  • Published online ahead of print. Publication date available at www.cjasn.org.

  • This article contains supplemental material online at http://cjasn.asnjournals.org/lookup/suppl/doi:10.2215/CJN.05890616/-/DCSupplemental.

  • Received June 4, 2016.
  • Accepted November 2, 2016.
  • Copyright © 2017 by the American Society of Nephrology

References

  1. ↵
    1. Wolfe RA,
    2. Ashby VB,
    3. Milford EL,
    4. Ojo AO,
    5. Ettenger RE,
    6. Agodoa LYC,
    7. Held PJ,
    8. Port FK
    : Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 341: 1725–1730, 1999pmid:10580071
    OpenUrlCrossRefPubMed
    1. Tonelli M,
    2. Wiebe N,
    3. Knoll G,
    4. Bello A,
    5. Browne S,
    6. Jadhav D,
    7. Klarenbach S,
    8. Gill J
    : Systematic review: Kidney transplantation compared with dialysis in clinically relevant outcomes. Am J Transplant 11: 2093–2109, 2011pmid:21883901
    OpenUrlCrossRefPubMed
    1. Rao PS,
    2. Merion RM,
    3. Ashby VB,
    4. Port FK,
    5. Wolfe RA,
    6. Kayler LK
    : Renal transplantation in elderly patients older than 70 years of age: Results from the scientific registry of transplant recipients. Transplantation 83: 1069–1074, 2007pmid:17452897
    OpenUrlCrossRefPubMed
    1. Kasiske BL,
    2. Cangro CB,
    3. Hariharan S,
    4. Hricik DE,
    5. Kerman RH,
    6. Roth D,
    7. Rush DN,
    8. Vazquez MA,
    9. Weir MR; American Society of Transplantation
    : The evaluation of renal transplantation candidates: Clinical practice guidelines. Am J Transplant 1[Suppl 2]: 3–95, 2001pmid:12108435
    OpenUrlPubMed
    1. Rebollo P,
    2. Ortega F,
    3. Baltar JM,
    4. Álvarez-Ude F,
    5. Alvarez Navascués R,
    6. Álvarez-Grande J
    : Is the loss of health-related quality of life during renal replacement therapy lower in elderly patients than in younger patients? Nephrol Dial Transplant 16: 1675–1680, 2001pmid:11477173
    OpenUrlCrossRefPubMed
    1. Humar A,
    2. Denny R,
    3. Matas AJ,
    4. Najarian JS
    : Graft and quality of life outcomes in older recipients of a kidney transplant. Exp Clin Transplant 1: 69–72, 2003pmid:15859911
    OpenUrlPubMed
  2. ↵
    1. Cornella C,
    2. Brustia M,
    3. Lazzarich E,
    4. Cofano F,
    5. Ceruso A,
    6. Barbé MC,
    7. Fenoglio R,
    8. Cella D,
    9. Stratta P
    : Quality of life in renal transplant patients over 60 years of age. Transplant Proc 40: 1865–1866, 2008pmid:18675072
    OpenUrlCrossRefPubMed
  3. ↵
    1. Saran R,
    2. Li Y,
    3. Robinson B,
    4. Ayanian J,
    5. Balkrishnan R,
    6. Bragg-Gresham J,
    7. Chen JT,
    8. Cope E,
    9. Gipson D,
    10. He K,
    11. Herman W,
    12. Heung M,
    13. Hirth RA,
    14. Jacobsen SS,
    15. Kalantar-Zadeh K,
    16. Kovesdy CP,
    17. Leichtman AB,
    18. Lu Y,
    19. Molnar MZ,
    20. Morgenstern H,
    21. Nallamothu B,
    22. O’Hare AM,
    23. Pisoni R,
    24. Plattner B,
    25. Port FK,
    26. Rao P,
    27. Rhee CM,
    28. Schaubel DE,
    29. Selewski DT,
    30. Shahinian V,
    31. Sim JJ,
    32. Song P,
    33. Streja E,
    34. Kurella Tamura M,
    35. Tentori F,
    36. Eggers PW,
    37. Agodoa LY,
    38. Abbott KC
    : US Renal Data System 2014 annual data report: Epidemiology of kidney disease in the United States. Am J Kidney Dis 66[Suppl 1]: S1–S305, 2015pmid:26111994
    OpenUrlCrossRefPubMed
    1. Pippias M,
    2. Stel VS,
    3. Abad Diez JM,
    4. Afentakis N,
    5. Herrero-Calvo JA,
    6. Arias M,
    7. Tomilina N,
    8. Bouzas Caamaño E,
    9. Buturovic-Ponikvar J,
    10. Čala S,
    11. Caskey FJ,
    12. Castro de la Nuez P,
    13. Cernevskis H,
    14. Collart F,
    15. Alonso de la Torre R,
    16. García Bazaga ML,
    17. De Meester J,
    18. Díaz JM,
    19. Djukanovic L,
    20. Ferrer Alamar M,
    21. Finne P,
    22. Garneata L,
    23. Golan E,
    24. González Fernández R,
    25. Gutiérrez Avila G,
    26. Heaf J,
    27. Hoitsma A,
    28. Kantaria N,
    29. Kolesnyk M,
    30. Kramar R,
    31. Kramer A,
    32. Lassalle M,
    33. Leivestad T,
    34. Lopot F,
    35. Macário F,
    36. Magaz A,
    37. Martín-Escobar E,
    38. Metcalfe W,
    39. Noordzij M,
    40. Palsson R,
    41. Pechter Ü,
    42. Prütz KG,
    43. Ratkovic M,
    44. Resić H,
    45. Rutkowski B,
    46. Santiuste de Pablos C,
    47. Spustová V,
    48. Süleymanlar G,
    49. Van Stralen K,
    50. Thereska N,
    51. Wanner C,
    52. Jager KJ
    : Renal replacement therapy in Europe: A summary of the 2012 ERA-EDTA registry annual report. Clin Kidney J 8: 248–261, 2015pmid:26034584
    OpenUrlCrossRefPubMed
  4. ↵
    1. Knoll GA
    : Kidney transplantation in the older adult. Am J Kidney Dis 61: 790–797, 2013pmid:23261121
    OpenUrlCrossRefPubMed
  5. ↵
    1. Schäeffner ES,
    2. Rose C,
    3. Gill JS
    : Access to kidney transplantation among the elderly in the United States: A glass half full, not half empty. Clin J Am Soc Nephrol 5: 2109–2114, 2010pmid:21030581
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Matas AJ,
    2. Smith JM,
    3. Skeans MA,
    4. Thompson B,
    5. Gustafson SK,
    6. Stewart DE,
    7. Cherikh WS,
    8. Wainright JL,
    9. Boyle G,
    10. Snyder JJ,
    11. Israni AK,
    12. Kasiske BL
    : OPTN/SRTR 2013 annual data report: Kidney. Am J Transplant 15[Suppl 2]: 1–34, 2015pmid:25626344
    OpenUrlCrossRefPubMed
  7. ↵
    1. Kutner NG,
    2. Zhang R,
    3. Bowles T,
    4. Painter P
    : Pretransplant physical functioning and kidney patients’ risk for posttransplantation hospitalization/death: Evidence from a national cohort. Clin J Am Soc Nephrol 1: 837–843, 2006pmid:17699295
    OpenUrlAbstract/FREE Full Text
  8. ↵
    1. Reese PP,
    2. Bloom RD,
    3. Shults J,
    4. Thomasson A,
    5. Mussell A,
    6. Rosas SE,
    7. Johansen KL,
    8. Abt P,
    9. Levine M,
    10. Caplan A,
    11. Feldman HI,
    12. Karlawish J
    : Functional status and survival after kidney transplantation. Transplantation 97: 189–195, 2014pmid:24113514
    OpenUrlCrossRefPubMed
    1. Kurella Tamura M,
    2. Yaffe K
    : Dementia and cognitive impairment in ESRD: Diagnostic and therapeutic strategies. Kidney Int 79: 14–22, 2011pmid:20861818
    OpenUrlCrossRefPubMed
    1. Wu C,
    2. Evans I,
    3. Joseph R,
    4. Shapiro R,
    5. Tan H,
    6. Basu A,
    7. Smetanka C,
    8. Khan A,
    9. McCauley J,
    10. Unruh M
    : Comorbid conditions in kidney transplantation: Association with graft and patient survival. J Am Soc Nephrol 16: 3437–3444, 2005pmid:16176999
    OpenUrlAbstract/FREE Full Text
    1. Doyle SE,
    2. Matas AJ,
    3. Gillingham K,
    4. Rosenberg ME
    : Predicting clinical outcome in the elderly renal transplant recipient. Kidney Int 57: 2144–2150, 2000pmid:10792636
    OpenUrlCrossRefPubMed
    1. Faravardeh A,
    2. Eickhoff M,
    3. Jackson S,
    4. Spong R,
    5. Kukla A,
    6. Issa N,
    7. Matas AJ,
    8. Ibrahim HN
    : Predictors of graft failure and death in elderly kidney transplant recipients. Transplantation 96: 1089–1096, 2013pmid:24056622
    OpenUrlCrossRefPubMed
    1. Karim A,
    2. Farrugia D,
    3. Cheshire J,
    4. Mahboob S,
    5. Begaj I,
    6. Ray D,
    7. Sharif A
    : Recipient age and risk for mortality after kidney transplantation in England. Transplantation 97: 832–838, 2014pmid:24342978
    OpenUrlCrossRefPubMed
    1. Kauffman HM,
    2. McBride MA,
    3. Cors CS,
    4. Roza AM,
    5. Wynn JJ
    : Early mortality rates in older kidney recipients with comorbid risk factors. Transplantation 83: 404–410, 2007pmid:17318072
    OpenUrlCrossRefPubMed
    1. Wedel N,
    2. Brynger H,
    3. Blohmè I
    : Kidney transplantation in patients 60 years and older. Scand J Urol Nephrol Suppl 54: 106–108, 1980pmid:7013026
    OpenUrlPubMed
    1. Ismail N,
    2. Hakim RM,
    3. Helderman JH
    : Renal replacement therapies in the elderly: Part II. Renal transplantation. Am J Kidney Dis 23: 1–15, 1994pmid:8285183
    OpenUrlPubMed
  9. ↵
    1. Meier-Kriesche HU,
    2. Ojo A,
    3. Hanson J,
    4. Cibrik D,
    5. Lake K,
    6. Agodoa LY,
    7. Leichtman A,
    8. Kaplan B
    : Increased immunosuppressive vulnerability in elderly renal transplant recipients. Transplantation 69: 885–889, 2000pmid:10755545
    OpenUrlCrossRefPubMed
  10. ↵
    1. Pinter J,
    2. Hanson CS,
    3. Craig JC,
    4. Chapman JR,
    5. Budde K,
    6. Halleck F,
    7. Tong A
    : ‘I feel stronger and younger all the time’-perspectives of elderly kidney transplant recipients: Thematic synthesis of qualitative research. Nephrol Dial Transplant 31: 1531–1540, 2016pmid:27333617
    OpenUrlCrossRefPubMed
  11. ↵
    1. Tong A,
    2. Sainsbury P,
    3. Craig J
    : Consolidated criteria for reporting qualitative research (COREQ): A 32-item checklist for interviews and focus groups. Int J Qual Health Care 19: 349–357, 2007pmid:17872937
    OpenUrlCrossRefPubMed
  12. ↵
    1. Hartmann EL,
    2. Kitzman D,
    3. Rocco M,
    4. Leng X,
    5. Klepin H,
    6. Gordon M,
    7. Rejeski J,
    8. Berry M,
    9. Kritchevsky S
    : Physical function in older candidates for renal transplantation: An impaired population. Clin J Am Soc Nephrol 4: 588–594, 2009pmid:19261824
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Zelle DM,
    2. Corpeleijn E,
    3. Stolk RP,
    4. de Greef MHG,
    5. Gans ROB,
    6. van der Heide JJH,
    7. Navis G,
    8. Bakker SJL
    : Low physical activity and risk of cardiovascular and all-cause mortality in renal transplant recipients. Clin J Am Soc Nephrol 6: 898–905, 2011pmid:21372213
    OpenUrlAbstract/FREE Full Text
  14. ↵
    1. Kasbia GS,
    2. Farragher J,
    3. Kim SJ,
    4. Famure O,
    5. Jassal SV
    : A cross-sectional study examining the functional independence of elderly individuals with a functioning kidney transplant. Transplantation 98: 864–870, 2014pmid:25321167
    OpenUrlCrossRefPubMed
  15. ↵
    1. Greenwood SA,
    2. Lindup H,
    3. Taylor K,
    4. Koufaki P,
    5. Rush R,
    6. Macdougall IC,
    7. Mercer TH
    : Evaluation of a pragmatic exercise rehabilitation programme in chronic kidney disease. Nephrol Dial Transplant 27[Suppl 3]: iii126–iii134, 2012pmid:22785111
    OpenUrlCrossRefPubMed
  16. ↵
    1. McAdams-Demarco MA,
    2. Grams ME,
    3. Hall EC,
    4. Coresh J,
    5. Segev DL
    : Early hospital readmission after kidney transplantation: Patient and center-level associations. Am J Transplant 12: 3283–3288, 2012pmid:23016838
    OpenUrlCrossRefPubMed
  17. ↵
    1. Dempster NJ,
    2. Ceresa CD,
    3. Aitken E,
    4. Kingsmore D
    : Outcomes following renal transplantation in older people: A retrospective cohort study. BMC Geriatr 13: 79, 2013pmid:23883109
    OpenUrlCrossRefPubMed
  18. ↵
    1. Schell JO,
    2. Patel UD,
    3. Steinhauser KE,
    4. Ammarell N,
    5. Tulsky JA
    : Discussions of the kidney disease trajectory by elderly patients and nephrologists: A qualitative study. Am J Kidney Dis 59: 495–503, 2012pmid:22221483
    OpenUrlCrossRefPubMed
  19. ↵
    1. Pollak KI,
    2. Childers JW,
    3. Arnold RM
    : Applying motivational interviewing techniques to palliative care communication. J Palliat Med 14: 587–592, 2011pmid:21291329
    OpenUrlCrossRefPubMed
  20. ↵
    1. Back AL,
    2. Arnold RM,
    3. Baile WF,
    4. Tulsky JA,
    5. Fryer-Edwards K
    : Approaching difficult communication tasks in oncology. CA Cancer J Clin 55: 164–177, 2005pmid:15890639
    OpenUrlCrossRefPubMed
  21. ↵
    1. Baile WF,
    2. Buckman R,
    3. Lenzi R,
    4. Glober G,
    5. Beale EA,
    6. Kudelka AP
    : SPIKES-A six-step protocol for delivering bad news: Application to the patient with cancer. Oncologist 5: 302–311, 2000pmid:10964998
    OpenUrlAbstract/FREE Full Text
  22. ↵
    1. Barry MJ,
    2. Edgman-Levitan S
    : Shared decision making—Pinnacle of patient-centered care. N Engl J Med 366: 780–781, 2012pmid:22375967
    OpenUrlCrossRefPubMed
  23. ↵
    1. Peters TG,
    2. Spinola KN,
    3. West JC,
    4. Aeder MI,
    5. Danovitch GM,
    6. Klintmalm GB,
    7. Gorman KJ,
    8. Gordon JA,
    9. Kincaid CH,
    10. First MR
    : Differences in patient and transplant professional perceptions of immunosuppression-induced cosmetic side effects. Transplantation 78: 537–543, 2004pmid:15446312
    OpenUrlPubMed
  24. ↵
    1. Reuben DB,
    2. Tinetti ME
    : Goal-oriented patient care—An alternative health outcomes paradigm. N Engl J Med 366: 777–779, 2012pmid:22375966
    OpenUrlCrossRefPubMed
  25. ↵
    1. O’Hare AM,
    2. Szarka J,
    3. McFarland LV,
    4. Taylor JS,
    5. Sudore RL,
    6. Trivedi R,
    7. Reinke LF,
    8. Vig EK
    : Provider perspectives on advance care planning for patients with kidney disease: Whose job is it anyway? Clin J Am Soc Nephrol 11: 855–866, 2016pmid:27084877
    OpenUrlAbstract/FREE Full Text
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Clinical Journal of the American Society of Nephrology: 12 (3)
Clinical Journal of the American Society of Nephrology
Vol. 12, Issue 3
March 07, 2017
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Perspectives of Older Kidney Transplant Recipients on Kidney Transplantation
Jule Pinter, Camilla S. Hanson, Jeremy R. Chapman, Germaine Wong, Jonathan C. Craig, Jane O. Schell, Allison Tong
CJASN Mar 2017, 12 (3) 443-453; DOI: 10.2215/CJN.05890616

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Perspectives of Older Kidney Transplant Recipients on Kidney Transplantation
Jule Pinter, Camilla S. Hanson, Jeremy R. Chapman, Germaine Wong, Jonathan C. Craig, Jane O. Schell, Allison Tong
CJASN Mar 2017, 12 (3) 443-453; DOI: 10.2215/CJN.05890616
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Keywords

  • geriatric nephrology
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  • Adolescent
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  • Australia
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  • goals
  • Graft Survival
  • humans
  • immunosuppression
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  • Longevity
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