Skip to main content

Main menu

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
American Society of Nephrology
  • Other
    • JASN
    • Kidney360
    • Kidney News Online
    • American Society of Nephrology
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Advertisement
American Society of Nephrology

Advanced Search

  • Home
  • Content
    • Published Ahead of Print
    • Current Issue
    • Podcasts
    • Subject Collections
    • Archives
    • ASN Meeting Abstracts
    • Saved Searches
  • Authors
    • Submit a Manuscript
    • Author Resources
    • Reprint Information
  • Trainees
    • Peer Review Program
    • Prize Competition
  • About CJASN
    • About CJASN
    • Editorial Team
    • CJASN Impact
    • CJASN Recognitions
  • More
    • Alerts
    • Advertising
    • Reprint Information
    • Subscriptions
    • Feedback
  • ASN Kidney News
  • Visit ASN on Facebook
  • Follow CJASN on Twitter
  • CJASN RSS
  • Community Forum

About the Cover

May 06, 2016; Volume 11,Issue 5

Cover image

Cover image expansion

On the Cover

What’s the diagnosis? A 56-year-old man with IgG kappa multiple myeloma presented with AKI. Serum free kappa light chains (LCs) were elevated at 326 mg/dL, the kappa/lambda ratio was 200, and urine kappa LCs were elevated at 239 mg/dL. Urinalysis revealed 1+ protein, and 1+ blood. Urine sediment analysis demonstrated aggregates of various shaped and sized crystals (cover image, panel insert), which had 25% birefringence with polarization. Kidney biopsy demonstrated LC crystalline casts and many tubular profiles showed LC crystals within the cytoplasm of the tubular epithelial cells and eosinophilic refractile LC crystals of varying shapes in tubular lumens (cover image). Electron microscopy revealed multifaceted crystals in the tubular lumens and within the cytoplasm of tubular epithelial cells (notshown). These finding were consistent with monoclonal LC-induced crystalline nephropathy as the cause of kidney injury. A 69-year-old man presented with an elevated creatinine of 2.3 mg/dL. Urinalysis revealed 1+ protein, 1+ glucose, pH 6.0 with protein/creatinine ratio 0.73 g/g. Urine microscopy showed casts that contained rhomboidal structures (left image below). Serum protein electrophoresis revealed an IgA kappa monoclonal component of 0.46 g/dL, and 6.1% of total protein. Kappa/lambda LC ratio was 314. Kidney biopsy demonstrated diffusely swollen proximal tubules packed with brightly eosinophilic granules. On ultrastructural exam, tubular epithelial cells were swollen due to intracytoplasmic accumulation of electron dense, membrane-bound, rhomboid or needle-shaped crystals some of which exhibited an organized structure (right image below). Bone marrow biopsy confirmed multiple myeloma with LC crystal tubulopathy. Monoclonal LCs are a known cause of various forms of kidney injury including cast nephropathy, amyloidosis, LC deposition disease and LC tubulopathy. Electron dense crystalline structures can be seen within the proximal tubular cell cytoplasm, which manifests as a proximal tubulopathy and sometimes a full-blown Fanconi syndrome. Less commonly recognized with these monoclonal LC diseases is the finding of lights chain crystals, both free and within casts, in the spun urine sediment. The presence of these same LC crystals within the tubular cell cytoplasm (both cases) as well as within renal tubular lumina (first case) on kidney biopsy confirmed the urinary sediment findings as LC crystals in these 2 cases. Thus, part of the evaluation of patients suspected of a paraprotein-related disease should include thorough evaluation of the spun urine sediment. (Images and text provided by Mark A. Perazella, MD, Yale University School of Medicine, New Haven, Connecticut, and Zita Shiue, MD and Ian deBoer, MD, Division of Nephrology, University of Washington and Roberto Nicosia, MD, Department of Pathology, University of Washington)

Back to top
PreviousNext

In this issue

Clinical Journal of the American Society of Nephrology: 11 (5)
Clinical Journal of the American Society of Nephrology
Vol. 11, Issue 5
May 06, 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Sign up for alerts
View Selected Citations (0)

Jump to

  • Editorials
  • Original Articles
    • Chronic Kidney Disease
    • Clinical Nephrology
    • Epidemiology and Outcomes
    • ESRD and Chronic Dialysis
    • Health Services Research
    • Hypertension
    • Renal Transplantation
  • Special Feature
  • Moving Points in Nephrology
  • Most Read
Loading
  • Revisiting Filtration Fraction as an Index of the Risk of Hemofilter Clotting in Continuous Venovenous Hemofiltration
  • Mitigating Risk of COVID-19 in Dialysis Facilities
  • COVID-19 and the Inpatient Dialysis Unit
  • COVID-19 in Patients with Kidney Disease
  • Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19
More...

Articles

  • Current Issue
  • Early Access
  • Subject Collections
  • Article Archive
  • ASN Meeting Abstracts

Information for Authors

  • Submit a Manuscript
  • Trainee of the Year
  • Author Resources
  • ASN Journal Policies
  • Reuse/Reprint Policy

About

  • CJASN
  • ASN
  • ASN Journals
  • ASN Kidney News

Journal Information

  • About CJASN
  • CJASN Email Alerts
  • CJASN Key Impact Information
  • CJASN Podcasts
  • CJASN RSS Feeds
  • Editorial Board

More Information

  • Advertise
  • ASN Podcasts
  • ASN Publications
  • Become an ASN Member
  • Feedback
  • Follow on Twitter
  • Password/Email Address Changes
  • Subscribe

© 2021 American Society of Nephrology

Print ISSN - 1555-9041 Online ISSN - 1555-905X

Powered by HighWire