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Original ArticlesRenal transplantation
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Emergency Department Visits after Kidney Transplantation

Jesse D. Schold, Nissreen Elfadawy, Laura D. Buccini, David A. Goldfarb, Stuart M. Flechner, Michael P. Phelan and Emilio D. Poggio
CJASN April 2016, 11 (4) 674-683; DOI: https://doi.org/10.2215/CJN.07950715
Jesse D. Schold
Departments of *Quantitative Health Sciences and
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Nissreen Elfadawy
†Glickman Urological and Kidney Institute, and
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Laura D. Buccini
‡Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio
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David A. Goldfarb
†Glickman Urological and Kidney Institute, and
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Stuart M. Flechner
†Glickman Urological and Kidney Institute, and
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Michael P. Phelan
§Emergency Medicine,
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Emilio D. Poggio
†Glickman Urological and Kidney Institute, and
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    Figure 1.

    Cumulative incidence of first emergency department visit following discharge for kidney transplantation. Cumulative incidence of time to first emergency department (ED) visit after discharge by (A) sex, (B) race/ethnicity, (C) prior ED use, and (D) primary insurance.

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    Figure 2.

    Rates of emergency department (ED) visits by transplant center. ID, identification.

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    Table 1.

    Study population characteristics compared with national adult solitary kidney transplant recipients in the United States (2009–2012)

    Recipient Characteristics and LevelStudy PopulationAdult Kidney Transplant Recipients in the United StatesP Value
    Age, yr
     Mean±SD51.3±13.751.4±13.60.49
    Sex, %
     Women40.039.20.14
    Primary insurance, %
     Medicare65.456.8<0.001
     Medicaid5.14.0
     Private28.737.5
     Other0.81.7
    Race/ethnicity, %
     White41.552.3<0.001
     Black19.126.0
     Hispanic22.814.6
     Asian/Pacific Islander8.25.9
     Other8.51.2
    Year of transplant, %
     200914.725.0<0.001
     201033.525.3
     201134.725.1
     201217.224.6
    N10,53363,903
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    Table 2.

    Rate of emergency department visits by recipient characteristics

    Recipient Characteristics and Level (% of Study Population)Rate of ED Visits after Transplantation per 100 patient-yr (95% CI)Adjusted Incidence Rate Ratio (95% CI)P Valuea
    Recipient age, yr
     18–29 (8)153.9 (146.5 to 161.4)1.28 (1.20 to 1.36)<0.001
     30–44 (25)131.4 (127.6 to 135.2)1.08 (1.04 to 1.13)
     45–59 (36)117.3 (114.3 to 120.3)0.99 (0.95 to 1.03)
     60+ (32)127.9 (124.4 to 131.3)Reference
    Recipient sexb
     Women (40)145.6 (142.4 to 148.8)1.25 (1.21 to 1.29)<0.001
     Men (60)114.5 (112.2 to 116.8)Reference
    Recipient race
     Black (19)155.5 (150.7 to 160.2)1.21 (1.16 to 1.26)<0.001
     Hispanic (23)142.4 (138.2 to 146.6)1.11 (1.06 to 1.15)
     Asian/Pacific Islander (8)94.5 (88.8 to 100.1)0.83 (0.78 to 0.89)
     Other (9)137.1 (129.6 to 144.6)1.15 (1.08 to 1.22)
     White (41)111.0 (108.4 to 113.7)Reference
    Primary insurance
     Medicare (65)142.2 (139.7 to 144.6)1.44 (1.39 to 1.50)<0.001
     Medicaid (5)181.0 (171.0 to 190.9)1.73 (1.61 to 1.85)
     Other (1)112.6 (92.6 to 132.7)1.20 (1.00 to 1.44)
     Private (29)84.8 (82.0 to 87.6)Reference
    Discharge site
     Other facility (2)180.1 (161.5 to 198.7)1.21 (1.08 to 1.34)<0.001
     Home health (19)163.5 (158.6 to 168.3)1.18 (1.14 to 1.22)
     Home/routine (80)117.2 (115.2 to 119.2)Reference
    Median income on the basis of residential zip codeb
     Lowest income quartile (25)141.7 (137.7 to 145.7)0.94 (0.85 to 1.04)0.17
     Second quartile (24)132.7 (128.7 to 136.6)1.01 (0.96 to 1.05)
     Third quartile (25)120.6 (117.0 to 124.2)0.99 (0.95 to 1.04)
     Highest income quartile (25)111.7 (108.1 to 115.3)Reference
    Depression
     Yes (4)145.5 (135.8 to 155.1)1.11 (1.04 to 1.19)0.003
     No (96)126.1 (124.2 to 128.0)Reference
    Hypertension
     Yes (8)143.6 (136.4 to 150.8)1.05 (1.00 to 1.11)0.07
     No (92)125.5 (123.6 to 127.5)Reference
    Diabetes, uncomplicated
     Yes (10)123.8 (117.9 to 129.7)1.02 (0.97 to 1.07)0.48
     No (90)127.3 (125.3 to 129.3)Reference
    Diabetes, with complications
     Yes (19)165.7 (160.7 to 170.6)1.32 (1.27 to 1.36)<0.001
     No (81)118.0 (116.0 to 120.0)Reference
    Congestive heart failure
     Yes (5)162.2 (152.2 to 172.1)1.11 (1.04 to 1.18)<0.001
     No (95)125.3 (123.4 to 127.2)Reference
    Peripheral vascular disease
     Yes (6)176.5 (167.2 to 185.7)1.29 (1.22 to 1.36)<0.001
     No (94)123.9 (122.0 to 125.8)Reference
    Hypothyroidism
     Yes (8)126.2 (119.8 to 132.6)1.00 (0.95 to 1.06)0.96
     No (92)127.0 (125.0 to 129.0)Reference
    Liver disease
     Yes (4)137.8 (128.2 to 147.3)1.08 (1.00 to 1.16)0.05
     No (96)126.5 (124.6 to 128.4)Reference
    Arthritis
     Yes (4)157.1 (145.7 to 168.5)1.05 (0.98 to 1.14)0.18
     No (96)125.9 (124.0 to 127.8)Reference
    Coagulopathy
     Yes (9)149.5 (142.5 to 156.5)1.12 (1.06 to 1.18)<0.001
     No (91)124.8 (122.9 to 126.8)Reference
    Valve disease
     Yes (5)117.1 (108.6 to 125.6)0.91 (0.84 to 0.98)<0.01
     No (95)127.4 (125.5 to 129.3)Reference
    Length of initial hospital stay, d
     1–4 (30)94.7 (91.7 to 97.7)Reference<0.001
     5–6 (36)118.2 (115.2 to 121.2)1.13 (1.08 to 1.17)
     7+ (34)162.3 (158.7 to 165.3)1.46 (1.41 to 1.53)
    ED visit within 1 yr before transplant
     Yes without admission (21)155.1 (150.7 to 159.5)1.58 (1.52 to 1.64)<0.001
     Yes with admission (29)177.6 (173.3 to 181.8)1.88 (1.82 to 1.95)
     No (50)87.2 (85.0 to 89.4)Reference
    State of residence
     California (47)121.4 (118.7 to 124.1)1.03 (0.99 to 1.07)0.22
     Florida (25)131.5 (127.7 to 135.3)1.00 (0.96 to 1.04)
     New York (28)132.5 (128.8 to 136.2)Reference
    Overall population
     n=10,533126.9 (125.1 to 128.8)
    • ED, emergency department; 95% CI, 95% confidence interval.

    • ↵a Statistical significance of recipient characteristics with adjusted incidence rate ratio.

    • ↵b Results for small proportions of missing values (<2%) not displayed.

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    Table 3.

    Most common primary clinical classification diagnoses codes for emergency department visits requiring and not requiring hospital admission among kidney transplant recipients postdischarge

    Diagnosis Description (CCS Code)aFrequency, %
    ED visits requiring hospital admission
     Complication of device; implant or graft (237)17.2
     Essential hypertension (99)6.5
     Diabetes mellitus with complications (50)5.6
     Septicemia (2)5.2
     Fluid and electrolyte disorders (55)4.2
     Acute and unspecified renal failure (157)3.9
     Congestive heart failure; nonhypertensive (108)3.8
     Pneumonia (122)3.6
     Urinary tract infections (159)3.6
     Complications of surgical procedures or medical care (238)3.3
     Nonspecific chest pain (102)2.1
     Intestinal infection (135)1.7
     Cardiac dysrhythmias (106)1.5
     Deficiency and other anemia (59)1.5
     Skin and subcutaneous tissue infections (197)1.3
    ED visits not requiring hospital admission
     Abdominal pain (251)7.8
     Urinary tract infections (159)4.9
     Fluid and electrolyte disorders (55)3.8
     Nonspecific chest pain (102)3.1
     Genitourinary symptoms and ill-defined conditions (163)3.1
     Nausea and vomiting (250)2.9
     Fever of unknown origin (246)2.8
     Diabetes mellitus with complications (50)2.7
     Other gastrointestinal disorders (155)2.7
     Superficial injury; contusion (239)2.6
     Other connective tissue disease (211)2.5
     Headache; including migraine (84)2.5
     Complication of device; implant or graft (237)2.4
     Sprains and strains (232)2.4
     Skin and subcutaneous tissue infections (197)2.2
    • CCS, Clinical Classifications Software; ED, emergency department.

    • ↵a These codes describe 65% of the cumulative diagnosis classifications for the study population in ED visits requiring hospital admission and 48% of the cumulative diagnosis classifications for the study population in ED visits not requiring hospital admission.

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Clinical Journal of the American Society of Nephrology: 11 (4)
Clinical Journal of the American Society of Nephrology
Vol. 11, Issue 4
April 07, 2016
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Emergency Department Visits after Kidney Transplantation
Jesse D. Schold, Nissreen Elfadawy, Laura D. Buccini, David A. Goldfarb, Stuart M. Flechner, Michael P. Phelan, Emilio D. Poggio
CJASN Apr 2016, 11 (4) 674-683; DOI: 10.2215/CJN.07950715

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Emergency Department Visits after Kidney Transplantation
Jesse D. Schold, Nissreen Elfadawy, Laura D. Buccini, David A. Goldfarb, Stuart M. Flechner, Michael P. Phelan, Emilio D. Poggio
CJASN Apr 2016, 11 (4) 674-683; DOI: 10.2215/CJN.07950715
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