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Renal Physiology
Open Access

Renal Control of Calcium, Phosphate, and Magnesium Homeostasis

Judith Blaine, Michel Chonchol and Moshe Levi
CJASN July 2015, 10 (7) 1257-1272; DOI: https://doi.org/10.2215/CJN.09750913
Judith Blaine
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado
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Michel Chonchol
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado
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Moshe Levi
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado
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Abstract

Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. Renal regulation of these ions occurs through glomerular filtration and tubular reabsorption and/or secretion and is therefore an important determinant of plasma ion concentration. Under physiologic conditions, the whole body balance of calcium, phosphate, and magnesium is maintained by fine adjustments of urinary excretion to equal the net intake. This review discusses how calcium, phosphate, and magnesium are handled by the kidneys.

  • renal physiology
  • calcium
  • cell and transport physiology
  • electrolytes
  • ion
  • channel
  • Copyright © 2015 by the American Society of Nephrology

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Clinical Journal of the American Society of Nephrology: 10 (7)
Clinical Journal of the American Society of Nephrology
Vol. 10, Issue 7
July 07, 2015
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Renal Control of Calcium, Phosphate, and Magnesium Homeostasis
Judith Blaine, Michel Chonchol, Moshe Levi
CJASN Jul 2015, 10 (7) 1257-1272; DOI: 10.2215/CJN.09750913

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Renal Control of Calcium, Phosphate, and Magnesium Homeostasis
Judith Blaine, Michel Chonchol, Moshe Levi
CJASN Jul 2015, 10 (7) 1257-1272; DOI: 10.2215/CJN.09750913
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More in this TOC Section

  • Acid-Base Homeostasis
  • Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters
  • Physiology of the Renal Interstitium
Show more Renal Physiology

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Keywords

  • renal physiology
  • calcium
  • cell and transport physiology
  • electrolytes
  • ion
  • channel

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