Article Information
PubMed
Published By
Print ISSN
Online ISSN
History
- Received March 7, 2014
- Accepted September 28, 2014
- Published online November 6, 2015.
Article Versions
- Earlier version (October 21, 2015 - 06:22).
- You are viewing the most recent version of this article.
Copyright & Usage
Copyright © 2015 by the American Society of Nephrology
Author Information
- Sanjay K. Nigam*,†,‡,
- Wei Wu*,
- Kevin T. Bush†,
- Melanie P. Hoenig§,
- Roland C. Blantz‖,¶,
- Vibha Bhatnagar**
- *Department of Medicine,
- †Department of Pediatrics,
- ‡Department of Cell & Molecular Medicine,
- ‖Division of Nephrology-Hypertension, and
- **Division of Family & Preventative Medicine, University of California–San Diego, La Jolla, California;
- ¶Veterans Affairs San Diego Healthcare System, San Diego, California; and
- §Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
- Correspondence:
Dr. Sanjay K. Nigam, Department of Pediatrics, Medicine (Nephrology) and Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0693. Email: snigam{at}ucsd.edu
Statistics from Altmetric.com
Article usage
Cited By...
In this issue
Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters
Jump to section
- Article
- Abstract
- Classification of Organic Ion Transporters
- Basic Organic Ion Transporter Physiology
- Drugs and Toxins
- Uremic Toxins
- Gut Microbiome Products, Nutrients, and Natural Products
- Metabolites and Signaling Molecules
- DDIs and Drug-Metabolite Interactions
- Pharmacogenomic and Toxicogenomic Considerations
- Pediatric Developmental Pharmacology and Drug Elimination in the Aging Population
- AKI and CKD
- Remote Sensing and Signaling Hypothesis
- Summary
- Disclosures
- Acknowledgments
- Footnotes
- References
- Figures & Data Supps
- Info & Metrics
- View PDF
More in this TOC Section
Cited By...
- Why Is the GFR So High?: Implications for the Treatment of Kidney Failure
- A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity
- Impaired Tubular Secretion of Organic Solutes in Acute Kidney Injury
- Kidney Clearance of Secretory Solutes Is Associated with Progression of CKD: The CRIC Study
- Diuretic Therapy for Patients With Heart Failure: JACC State-of-the-Art Review
- A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease
- Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning
- Clinical Pharmacology in Diuretic Use
- Dynamics of Organic Anion Transporter-Mediated Tubular Secretion during Postnatal Human Kidney Development and Maturation
- Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects
- Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
- Uric acid stones, clinical manifestations and therapeutic considerations
- Residual Function Effectively Controls Plasma Concentrations of Secreted Solutes in Patients on Twice Weekly Hemodialysis
- Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity
- Prediction of the Effects of Renal Impairment on Clearance for Organic Cation Drugs that Undergo Renal Secretion: A Simulation-Based Study
- Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys
- The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut-liver-kidney axis
- Disposition and clinical implications of protein-bound uremic toxins
- Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins
- Diurnal and Long-term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion
- Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?
- Multiple Drug Transporters Are Involved in Renal Secretion of Entecavir
- Molecular Properties of Drugs Interacting with SLC22 Transporters OAT1, OAT3, OCT1, and OCT2: A Machine-Learning Approach
- An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network
- Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers