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Nephrolithiasis
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Comparative Value of Orange Juice versus Lemonade in Reducing Stone-Forming Risk

Clarita V. Odvina
CJASN November 2006, 1 (6) 1269-1274; DOI: https://doi.org/10.2215/CJN.00800306
Clarita V. Odvina
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    Figure 1.

    Effect of lemonade and orange juice on net gastrointestinal absorption of alkali. Horizontal lines indicate group means. •, normal volunteers; ○, stone formers. *P < 0.05 versus control; †P < 0.05 versus lemonade.

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    Figure 2.

    Effect of lemonade and orange juice on titratable acidity. Horizontal lines indicate group means. •, normal volunteers; ○, stone formers. *P < 0.05 versus control; †P < 0.05 versus lemonade.

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    Figure 3.

    Effect of lemonade and orange juice on urinary citrate excretion. Horizontal lines indicate group means. •, normal volunteers; ○, stone formers. *P < 0.05 versus control; †P < 0.05 versus lemonade.

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    Figure 4.

    Effect of lemonade and orange juice on urinary pH. Horizontal lines indicate group means. •, normal volunteers; ○, stone formers. *P < 0.05 versus control; †P < 0.05 versus lemonade.

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    Table 1.

    Serum chemistries of the study participants according to intervention perioda

    ParameterControlLemonadeOrange JuiceANOVA P
    BUN (mg/dl)11 ± 310 ± 311 ± 3b<0.05
    Cr (mg/dl)0.9 ± 0.20.9 ± 0.20.9 ± 0.20.61
    Na+ (mEq/L)138 ± 2138 ± 2137 ± 20.31
    K+ (mEq/L)4.2 ± 0.34.3 ± 0.34.4 ± 0.30.22
    Cl− (mEq/L)105 ± 2105 ± 3104 ± 20.35
    CO2 (mEq/L)28 ± 229 ± 229 ± 20.11
    Ca2+ (mg/dl)9.3 ± 0.39.3 ± 0.39.3 ± 0.20.95
    Pi (mg/dl)3.4 ± 0.43.2 ± 0.63.4 ± 0.40.10
    Mg2+ (mg/dl)2.2 ± 0.22.2 ± 0.12.2 ± 0.10.19
    UA (mg/dl)6.6 ± 1.66.2 ± 1.65.6 ± 1.5b,c<0.0001
    • ↵a Data are mean ± SD. BUN, blood urea nitrogen; Ca2+, calcium; Cl−, chloride; CO2, total carbon dioxide; Cr, creatinine; K+, potassium; Mg2+, magnesium; Na+, sodium; Pi, inorganic phosphorus; UA, uric acid.

    • ↵b P < 0.05 versus lemonade.

    • ↵c P < 0.05 versus control.

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    Table 2.

    Twenty-four-hour urine values according to intervention perioda

    ParameterControlLemonadeOrange JuiceANOVA P
    Total volume (L/d)2.55 ± 0.542.61 ± 0.312.51 ± 0.350.51
    Ca2+ (mg/d)159 ± 42154 ± 58146 ± 520.32
    Mg2+ (mg/d)83 ± 2386 ± 21108 ± 28b,c<0.0001
    Cr (mg/d)1589 ± 3491565 ± 3641585 ± 3150.81
    Na+ (mEq/d)70 ± 3758 ± 3166 ± 480.28
    K+ (mEq/d)38 ± 1139 ± 785 ± 21b,c<0.0001
    Ammonium (mEq/d)37 ± 1036 ± 923 ± 8b,c<0.0001
    Oxalate (mg/d)31 ± 1030 ± 735 ± 6b,c<0.005
    UA (mg/d)527 ± 123491 ± 81533 ± 1160.22
    Calculated RSR CaOx4.50 ± 1.514.26 ± 1.843.71 ± 1.58b0.06
    Calculated RSR Br0.42 ± 0.270.32 ± 0.210.82 ± 0.56b,c<0.0001
    Calculated undissociated UA (mg/d)184 ± 97181 ± 8877 ± 67b,c<0.0001
    NAE (mEq/d)55.5 ± 16.348.9 ± 15.717.3 ± 20.8b,c<0.0001
    • ↵a Data are mean ± SD. Br, brushite; CaOx, calcium oxalate; NAE, net acid excretion; RSR, relative supersaturation.

    • ↵b P < 0.05 versus control.

    • ↵c P < 0.05 versus lemonade.

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Clinical Journal of the American Society of Nephrology
Vol. 1, Issue 6
November 2006
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Comparative Value of Orange Juice versus Lemonade in Reducing Stone-Forming Risk
Clarita V. Odvina
CJASN Nov 2006, 1 (6) 1269-1274; DOI: 10.2215/CJN.00800306

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Comparative Value of Orange Juice versus Lemonade in Reducing Stone-Forming Risk
Clarita V. Odvina
CJASN Nov 2006, 1 (6) 1269-1274; DOI: 10.2215/CJN.00800306
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