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Acid/Base and Electrolyte Disorders
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Age-Related Increase in Plasma Urea Level and Decrease in Fractional Urea Excretion: Clinical Application in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Wim Musch, Lies Verfaillie and Guy Decaux
CJASN September 2006, 1 (5) 909-914; DOI: https://doi.org/10.2215/CJN.00320106
Wim Musch
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Lies Verfaillie
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Guy Decaux
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    Figure 1.

    Relationships between plasma urea and age (top; y = 0.229x + 18.26; r = 0.62; P < 0.001) and lack of correlation between plasma creatinine and age (bottom) in 107 patients.

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    Figure 2.

    Relationship between fractional urea excretion (FE urea) and age (top; y = −0.226x + 55; r = −0.41; P < 0.001) and between fractional sodium excretion (FENa) and age (bottom; y = 0.0046x + 0.365; r = 0.27; P < 0.02) in 87 patients with an urinary-to-plasma creatinine ratio between 50 and 150.

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    Table 1.

    Comparison of daily urea and creatinine excretion in 19 young women (<40 yr) and 15 old women (>70 yr)a

    Young Women(n = 19)Old Women(n = 15)
    Age (yr)31 ± 775 ± 6
    Weight (kg)59 ± 1564 ± 9
    Diuresis (L/24 h)1.3 ± 0.61.1 ± 0.7
    P Na (mEq/L)140 ± 2141 ± 3
    P urea (mg/dl)25 ± 736 ± 7b
    P creat (mg/dl)0.8 ± 0.10.9 ± 0.1
    P UA (mg/dl)3.9 ± 1.54.2 ± 1
    U osm (mOsm/kg)684 ± 238414 ± 119b
    FENa (%)0.7 ± 0.31.1 ± 0.5c
    FE urea (%)52 ± 1542 ± 10d
    V/CrCl (%)0.9 ± 0.51.8 ± 0.7b
    CrCl (ml/min)107 ± 2661 ± 16b
    Urea clearance (ml/min)57 ± 2525 ± 8b
    Cr excretion (mg/kg 24 h)18.9 ± 2.310.9 ± 1.5b
    Urea excretion (mg/kg 24 h)270 ± 61196 ± 50c
    Osmole excretion (mOsm/kg 24 h)13.9 ± 5.26.5 ± 3.9b
    • ↵a Data are means ± SD. CrCl, creatinine clearance; creat, creatinine; FE, fractional excretion; P, plasma.

    • ↵b P < 0.001 versus young women.

    • ↵c P < 0.01 versus young women.

    • ↵d P < 0.05 versus young women.

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    Table 2.

    Comparison of usual biochemical parameters of 14 young patients with SIADH, 28 young control subjects, 18 old patients with SIADH, and 36 old control subjectsa

    Young Patients with SIADH(n = 14; 5 W/9 M)Young Control Subject(n = 28; 10 W/18 M)Old Patients with SIADH(n = 18; 10 W/8 M)Old Control Subjects(n = 36; 20 W/16 M)
    Age (yr)45 ± 943 ± 675 ± 577 ± 8
    P Na (mEq/L)126 ± 3140 ± 2125 ± 5140 ± 2
    P urea (mg/dl)18 ± 8b,d27 ± 729 ± 839 ± 8c,d
    P creat (mg/dl)0.7 ± 0.1c0.9 ± 0.10.8 ± 0.20.9 ± 0.2
    P UA (mg/dl)2.4 ± 0.8c5 ± 1.62.8 ± 0.95.4 ± 1.5d
    U osm (mOsm/kg)498 ± 162515 ± 212530 ± 153582 ± 159
    FE Na (%)0.8 ± 0.40.6 ± 0.20.7 ± 0.30.7 ± 0.3
    FE urea (%)58 ± 14b,e46 ± 1044 ± 1536 ± 9c,e
    FE UA (%)16 ± 6c8 ± 414 ± 69 ± 4f
    V/CrCl × 100 (%)1 ± 0.31.1 ± 0.41 ± 0.41.1 ± 0.4
    • ↵a Data are means ± SD. SIADH, syndrome of inappropriate secretion of antidiuretic hormone.

    • ↵b P < 0.01,

    • ↵c P < 0.001 versus young control subjects.

    • ↵d P < 0.001,

    • ↵e P < 0.02,

    • ↵f P < 0.01 versus old patients with SIADH.

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Clinical Journal of the American Society of Nephrology
Vol. 1, Issue 5
September 2006
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Age-Related Increase in Plasma Urea Level and Decrease in Fractional Urea Excretion: Clinical Application in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Wim Musch, Lies Verfaillie, Guy Decaux
CJASN Sep 2006, 1 (5) 909-914; DOI: 10.2215/CJN.00320106

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Age-Related Increase in Plasma Urea Level and Decrease in Fractional Urea Excretion: Clinical Application in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Wim Musch, Lies Verfaillie, Guy Decaux
CJASN Sep 2006, 1 (5) 909-914; DOI: 10.2215/CJN.00320106
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