Received August 28, 2008
Accepted on September 23, 2008

ORIGINAL ARTICLES

Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation

Frank P. Hurst ^*1, Robert T. Neff ^*, Edward M. Falta , Rahul M. Jindal , Krista L. Lentine , John S. Swanson ^||, Lawrence Y. Agodoa ^¶, and Kevin C. Abbott ^*

*Nephrology Service, Organ Transplant Service, Walter Reed Army Medical Center, Washington, District of Columbia; Uniformed Services University of Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland; Center for Outcomes Research, Division of Nephrology, St. Louis University School of Medicine, St. Louis, Missouri; ||Organ Transplant Service, Christiana Care Health Network, Newark, Delaware; ¶National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland

¹ To whom correspondence should be addressed. E-mail: frank.hurst{at}us.army.mil.

	Abstract

Background and objectives: Renal transplantation is increasingly performed in elderly patients, and the incidence of benign prostatic hyperplasia (BPH) increases with age. Anuric males on dialysis may have occult BPH and not develop obstructive symptoms until urine flow is restored after transplantation. If left untreated, BPH poses a risk for numerous complications, including acute urinary retention (AUR), recurrent urinary tract infections (UTI), and renal failure. The authors hypothesized that incident BPH after renal transplantation would adversely affect allograft survival.

Design, setting, participants, & measurements: Medicare claims for BPH, AUR, UTI, and prostate resection procedures (transurethral resection of the prostate; TURP) were assessed in a retrospective cohort of 23,622 adult male Medicare primary renal transplant recipients in the United States Renal Data System database who received transplants from 1 January 2000 to 31 July 2005 and followed through 31 December 2005.

Results: The 3-yr incidence of BPH post-transplant was 9.7%. The incidences of AUR, UTI, and TURP after BPH diagnosis (up to 3 yr posttransplant) were 10.3%, 6.5%, and 7.3% respectively, and each was significantly associated with BPH. Cox regression analysis showed that recipient age per year, later year of transplant, and dialysis vintage were associated with incident BPH. Using Cox nonproportional hazards regression, BPH was significantly associated with renal allograft loss (including death).

Conclusions: BPH is common in males after renal transplant and is independently associated with AUR, UTI, and graft loss. It is unknown whether treatment of BPH, either medical or surgical, attenuates these risks.