Idiopathic IgA Nephropathy: Pathogenesis, Histopathology, and Therapeutic Options
James A. Tumlin *1,
Michael P. Madaio 
,
and
Randolph Hennigar 
*Clinical Research Division, Southeast Renal Associates, Charlotte, North Carolina; Nephrology and Kidney Transplantation Section, Temple University, Philadelphia, Pennsylvania; and Department of Pathology, Emory University, Atlanta, Georgia
1 To whom correspondence should be addressed. E-mail: jtumlin{at}emory.edu.
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Abstract |
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IgA nephropathy is one of the most common causes of glomerulonephritis in the world. Proliferative and crescentic forms of IgA are found in up to 30% of cases and are associated with nephrotic-range proteinuria, accelerated hypertension, and accelerated decline toward ESRD. Despite its prevalence and clinical importance, there is no unifying nomenclature or consensus for the treatment of specific histologic subgroups. As a consequence, the development of clinically effective treatment regimens for IgA nephropathy have lagged behind other, less common forms of glomerulonephritis. Herein is reviewed the pathogenesis and histologic subtypes of IgA nephropathy and how conventional and immunosuppressive therapies have an impact on renal survival and recurrence rates. The use of known clinical risk factors for disease progression in conjunction with specific histologic features can be a guide to both induction and consolidation therapies for individual patients with IgA nephropathy.
