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Received March 9, 2007
Accepted on June 19, 2007
ORIGINAL ARTICLES |
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1,
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*Clinical Research Centre for Rare Diseases "Aldo e Cele Daccò," Mario Negri Institute for Pharmacological Research, Villa Camozzi, Ranica, and
Unit of Nephrology, Azienda Ospedaliera Ospedali Riuniti, Bergamo, Italy
1 To whom correspondence should be addressed. E-mail: manuelap{at}marionegri.it.
| Abstract |
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Background and Objectives: Rituximab, given in four weekly doses, is a promising treatment for idiopathic membranous nephropathy and other immune-mediated diseases and lymphoproliferative disorders. This multidose regimen, however, may cause hypersensitivity reactions and is extremely expensive. This study was aimed at evaluating whether titrating rituximab to circulating CD20 B cells may improve safety and limit costs of treatment.
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