Moving Points in Nephrology
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Mechanisms and Role of HLA and non-HLA Alloantibodies
Kathryn J. Tinckam 1
and
Anil Chandraker
Transplantation Research Center, Brigham and Women’s Hospital, Boston, Massachusetts
1 To whom correspondence should be addressed. E-mail: ktinckam{at}rics.bwh.harvard.edu.
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Abstract |
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The role of alloantibodies against HLA and non-HLA targets is becoming increasingly recognized as critical in the pathogenesis of acute and chronic renal allograft outcomes. This review discusses the antigenic targets, the mechanisms of T and B cell activation that result in the production of antibody, the complement cascade, methods of antibody detection, and the evidence that alloantibody-mediated mechanisms are active in acute and chronic rejection.
