CJASN
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published ahead of print on January 10, 2007
Clin J Am Soc Nephrol 2: 304-312, 2007
© 2007 American Society of Nephrology
doi: 10.2215/CJN.03401006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
CJN.03401006v1
2/2/304    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bankir, L.
Right arrow Articles by Weinberger, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bankir, L.
Right arrow Articles by Weinberger, M. H.
Related Collections
Right arrowRelated Articles

Hypertension

Ethnic Differences in Urine Concentration: Possible Relationship to Blood Pressure

Lise Bankir*,{dagger}, Julie Perucca*,{dagger}, and Myron H. Weinberger{ddagger}

* INSERM, Unité 652, and {dagger} Université Paris Descartes, Centre des Cordeliers, Paris, France; and {ddagger} Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana

Address correspondence to: Dr. Lise Bankir, INSERM Unité 652, 17 Rue du Fer à Moulin, 75005 Paris, France. Phone: +33-1-45-87-61-21; Fax: +33-1-45-35-66-29; E-mail: bankir{at}fer-a-moulin.inserm.fr

The mechanisms that account for the susceptibility of black individuals to hypertension and their reduced ability to excrete sodium are poorly understood. Vasopressin administration has been shown in healthy humans to delay sodium excretion along with its antidiuretic action. Black individuals have been reported to have higher vasopressin levels than white individuals. Therefore, this study investigated retrospectively 24-h urine volume (V) and urine concentration index (urine-to-plasma ratio of creatinine concentration), as well as their possible relationships with BP, in a cohort of 141 healthy young black and white individuals (18 to 40 y). Black individuals were found to have a significantly lower V and higher urine concentration than white individuals, especially during daytime. In addition, they exhibited a blunted nocturnal fall in fluid and electrolyte excretion and a higher pulse pressure than white individuals. Higher urine concentration and lower V were associated significantly with higher PP (but not with systolic or diastolic BP) in men. These relations remained significant after adjustment for age, body mass index, and sodium and potassium excretion. These results suggest that an enhanced tendency to concentrate urine may delay the excretion of the daily ingested fluid and sodium and may increase pulse pressure in young normotensive individuals. The higher urine concentration that is observed in black individuals (which could represent an adaptation to better water conservation) may participate in their enhanced susceptibility to hypertension. If these results are confirmed in further studies, then vasopressin V2 receptor antagonists might offer a novel antihypertensive strategy, especially in the black population.


Related Articles

Vasopressin, Urine Concentration, and Hypertension: A New Perspective on an Old Story
Friedrich C. Luft
Clin. J. Am. Soc. Nephrol. 2007 2: 196-197. [Full Text] [PDF]

Urea and Renal Function in the 21st Century: Insights from Knockout Mice
Robert A. Fenton and Mark A. Knepper
J. Am. Soc. Nephrol. 2007 18: 679-688. [Abstract] [Full Text] [PDF]

Critical Role of Urea in the Urine-Concentrating Mechanism
Jeff M. Sands
J. Am. Soc. Nephrol. 2007 18: 670-671. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
K. M. Moritz, R. R. Singh, M. E. Probyn, and K. M. Denton
Developmental programming of a reduced nephron endowment: more than just a baby's birth weight
Am J Physiol Renal Physiol, January 1, 2009; 296(1): F1 - F9.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Perucca, D. G. Bichet, P. Bardoux, N. Bouby, and L. Bankir
Sodium Excretion in Response to Vasopressin and Selective Vasopressin Receptor Antagonists
J. Am. Soc. Nephrol., September 1, 2008; 19(9): 1721 - 1731.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T.-Y. Chun, L. Bankir, G. J. Eckert, D. G. Bichet, C. Saha, S.-A. Zaidi, M. A. Wagner, and J. H. Pratt
Ethnic Differences in Renal Responses to Furosemide
Hypertension, August 1, 2008; 52(2): 241 - 248.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Burnier
Ethnic Differences in Renal Handling of Water and Solutes in Hypertension
Hypertension, August 1, 2008; 52(2): 203 - 204.
[Full Text] [PDF]

Home page
 HypertensionHome page
L. Bankir, M. Bochud, M. Maillard, P. Bovet, A. Gabriel, and M. Burnier
Nighttime Blood Pressure and Nocturnal Dipping Are Associated With Daytime Urinary Sodium Excretion in African Subjects
Hypertension, April 1, 2008; 51(4): 891 - 898.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society of Nephrology.