CJASN
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published ahead of print on July 23, 2008
Clinical Journal of the American Society of Nephrology
© 2008 American Society of Nephrology
doi: 10.2215/CJN.01400308
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
CJN.01400308v1
3/6/1807    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Patel, R. K.
Right arrow Articles by Jardine, A. G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Patel, R. K.
Right arrow Articles by Jardine, A. G.

Received March 22, 2008
Accepted on June 17, 2008

ORIGINAL ARTICLES

Renal Transplantation Is Not Associated with Regression of Left Ventricular Hypertrophy: A Magnetic Resonance Study

Rajan K. Patel *{dagger}, Patrick B. Mark *{dagger}, Nicola Johnston {ddagger}, Ellon McGregor {dagger}, Henry J. Dargie {ddagger}, and Alan G. Jardine *{dagger}1

*BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom; and Departments of {dagger}Renal Medicine and {ddagger}Cardiology, Western Infirmary, Glasgow, United Kingdom


1 To whom correspondence should be addressed. E-mail: a.g.jardine{at}clinmed.gla.ac.uk.


  Abstract

Background and objectives: Patients with end-stage renal failure (ESRD) have an increased risk of premature cardiovascular (CV) disease. Left ventricular hypertrophy is an independent risk factor for CV events and death in ESRD. Renal transplantation has been associated with reduction in CV risk and echocardiographic regression of left ventricular hypertrophy. However, echocardiography overestimates LV mass in ESRD patients. Cardiac magnetic resonance (CMR) provides more detailed, volume-independent, measures of cardiac structure. Changes in LV mass measured by CMR after renal transplantation were studied.

Design, setting, participants, & measurements: Fifty patients underwent CMR on two occasions. Twenty-five were transplanted before the second scan. CMR was performed to measure LV mass index (LVMI), ejection fraction, end-diastolic and end-systolic volumes. Changes were expressed as percentage change over time. Patients with CV events between scans (e.g., acute coronary syndrome, myocardial infarction) were excluded. All transplant patients had serum creatinine <150 µmol/L.

Results: There was no significant change in LVMI between patients who underwent renal transplantation and those who remained on dialysis (transplanted mean, 2.75%/yr, ± 9.1 versus dialysis, -3.6%/yr ± 16.7). In addition, there were no significant changes in end-diastolic volume (transplant, 0.1%/yr ± 19.5 versus not transplanted, -3.4%/yr ± 31.5), end-systolic volume (transplanted mean, 15.2%/yr ± 65.2 versus not transplanted, 3.0%/yr ± 55.5), or ejection fraction (transplant, 2.1%/yr ± 11.9 versus not transplanted, -0.4%/yr ± 5.3).

Conclusions: Renal transplantation is not associated with significant regression of LVMI on CMR compared with patients who remain on the transplant waiting list.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2008 by the American Society of Nephrology.