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Half of Kidney Transplant Candidates Who Are Older than 60 Years Now Placed on the Waiting List Will Die before Receiving a Deceased-Donor Transplant

Jesse Schold^*,,, Titte R. Srinivas, Ashwini R. Sehgal^||,¶, and Herwig-Ulf Meier-Kriesche^*

Departments of ^* Medicine, Health Services Research, Management and Policy, and Epidemiology and Health Policy Research, University of Florida, Gainesville, Florida; Department of Nephrology and Hypertension, Glickman Kidney and Urological Institute, Cleveland Clinic, ^|| Division of Nephrology, MetroHealth Medical Center, and ^¶ Center for Reducing Health Disparities, Case Western Reserve University, Cleveland, Ohio

Correspondence: Dr. Jesse D. Schold, P.O. Box 100224, University of Florida, Gainesville, FL 32610-0224. Phone: 352-846-2692; Fax: 352-392-5465; E-mail: scholjd{at}medicine.ufl.edu

Background and objectives: Waiting times to deceased-donor transplantation (DDTx) have significantly increased in the past decade. This trend particularly affects older candidates given a high mortality rate on dialysis.

Design, setting, participants, & measurements: We conducted a retrospective analysis from the national Scientific Registry of Transplant Recipients database that included 54,669 candidates who were older than 60 yr and listed in the United States for a solitary kidney transplant from 1995 through 2007. Using survival models, we estimated time to DDTx and mortality after candidate listing with and without patients initially listed as temporarily inactive (status 7).

Results: Almost half (46%) of candidates who were older than 60 yr and listed in 2006 through 2007 are projected to die before receiving a DDTx. This proportion varied by individual characteristics: Diabetes (61%), age 70 yr (52%), black (62%), blood types O (60%) and B (71%), highly sensitized (68%), and on dialysis at listing (53%). Marked variation also existed by United Network for Organ Sharing region (6 to 81%). The overall projected proportion was reduced to 35% excluding patients who initially were listed as status 7.

Conclusions: These data highlight the prominent and growing challenge facing the field of kidney transplantation. Older candidates are now at significant risk for not surviving the interval in which a deceased-donor transplant would become available. Importantly, this risk is variable within this population, and specific information should be disseminated to patients and caregivers to facilitate informed decision-making and potential incentives to seek living donors.