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This Article Full Text Full Text (PDF) Press Release All Versions of this Article: CJN.00670109v1 4/7/1213    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Lentine, K. L. Articles by Brennan, D. C. PubMed PubMed Citation Articles by Lentine, K. L. Articles by Brennan, D. C. Related Collections Related Article

Sensitivity of Billing Claims for Cardiovascular Disease Events among Kidney Transplant Recipients

Krista L. Lentine^*, Mark A. Schnitzler^*, Kevin C. Abbott, Kosha Bramesfeld, Paula M. Buchanan^*, and Daniel C. Brennan

^* Center for Outcomes Research and Division of Nephrology, School of Medicine, and Department of Research Methodology, Graduate School, Saint Louis University, and Division of Nephrology, Washington University School of Medicine, St. Louis, Missouri; and Nephrology Service, Walter Reed Army Medical Center, Washington, DC

Correspondence: Dr. Krista L. Lentine, Saint Louis University Center for Outcomes Research, Salus Center 2nd Floor, 3545 Lafayette Avenue, St. Louis, MO 63104. Phone: 314-977-9477; Fax: 314-977-1101; E-mail: lentine.krista{at}stanfordalumni.org

Background and objectives: Billing claims are increasingly examined beyond administrative functions as outcomes measures in observational research. Few studies have described the performance of billing claims as surrogate measures of clinical events among kidney transplant recipients.

Design, setting, participants, & measurements: We investigated the sensitivity of Medicare billing claims for clinically verified cardiovascular diagnoses (five categories) and procedures (four categories) in a novel database linking Medicare claims to electronic medical records of one transplant program. Cardiovascular events identified in medical records for 571 Medicare-insured transplant recipients in 1991 through 2002 served as reference measures.

Results: Within a claims-ascertainment period spanning ±30 d of clinically recorded dates, aggregate sensitivity of single claims was higher for case definitions incorporating Medicare Parts A and B for diagnoses and procedures (90.9%) compared with either Part A (82.3%) or Part B (84.6%) alone. Perfect capture of the four procedures was possible within ±30 d or with short claims window expansion, but sensitivity for the diagnoses trended lower with all study algorithms (91.2% with window up to ±90 d). Requirement for additional confirmatory diagnosis claims did not appreciably reduce sensitivity. Sensitivity patterns were similar in the early compared with late periods of the study.

Conclusions: Combined use of Medicare Parts A and B billing claims composes a sensitive measure of cardiovascular events after kidney transplant. Further research is needed to define algorithms that maximize specificity as well as sensitivity of claims from Medicare and other insurers as research measures in this population.

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Reliability of Medicare Claim Forms for Outcome Studies in Kidney Transplant Recipients: Epidemiology in Clinical Outcome Trials

Lisa Nanovic and Bruce Kaplan
Clin. J. Am. Soc. Nephrol. 2009 4: 1156-1158. [Full Text] [PDF]

This article has been cited by other articles:

				L. Nanovic and B. Kaplan Reliability of Medicare Claim Forms for Outcome Studies in Kidney Transplant Recipients: Epidemiology in Clinical Outcome Trials Clin. J. Am. Soc. Nephrol., July 1, 2009; 4(7): 1156 - 1158. [Full Text] [PDF]