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In-center Nocturnal Hemodialysis: Another Option in the Management of Chronic Kidney Disease

Ann Bugeja^*, Niki Dacouris, Alison Thomas, Rosa Marticorena, Philip McFarlane^,, Sandra Donnelly^,, and Marc Goldstein^,

^* Division of Nephrology, Kidney Research Centre, Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, and Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Division of Nephrology, University of Toronto, Toronto, Ontario, Canada

Correspondence: Dr. Marc Goldstein, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8. Phone: 416-864-5290; Fax: 416-864-3042; E-mail: marc.goldstein{at}utoronto.ca

Background and objectives: Some patients are not optimally treated by conventional in-center hemodialysis (HD) and are unable to perform home HD. We examined the effect of in-center thrice-weekly nocturnal HD (INHD) on patient outcomes.

Design, setting, participants, & measurements: Patients who were not optimally treated on conventional HD were offered INHD. Thirty-nine patients’ laboratory data and medication use were analyzed for the 12 mo before and after conversion to INHD until September 1, 2007. Quality of life on conventional HD and INHD was compared.

Results: After conversion to INHD, median values for phosphorus decreased from 5.9 to 3.7 mg/dl (P < 0.01), alkaline phosphatase level increased from 84 to 161 U/L (P < 0.01), and percentage reduction in urea increased from 74 to 89% (P < 0.01). The mean number of antihypertensive drugs prescribed declined from 2.0 to 1.5 (P < 0.05) during the course of INHD, and the mean daily dosage of phosphate binders declined from 6.2 to 4.9 at study end (P < 0.05). There was a significant reduction in erythropoietin-stimulating agent use of 1992 U/wk (P < 0.01). There was no significant change in median hemoglobin, iron saturation, corrected calcium, or parathyroid hormone levels. Overall, quality of life, sleep, intradialytic cramps, appetite, and energy level all improved significantly on INHD.

Conclusions: INHD offers an effective form of HD for long-term dialysis patients who are unable to perform home HD.

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New Options to Improve Hemodialysis Patient Outcomes

Alan S. Kliger
Clin. J. Am. Soc. Nephrol. 2009 4: 694-695. [Full Text] [PDF]

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				R. P. Pauly, J. S. Gill, C. L. Rose, R. A. Asad, A. Chery, A. Pierratos, and C. T. Chan Survival among nocturnal home haemodialysis patients compared to kidney transplant recipients Nephrol. Dial. Transplant., September 1, 2009; 24(9): 2915 - 2919. [Abstract] [Full Text] [PDF]

				A. S. Kliger New Options to Improve Hemodialysis Patient Outcomes Clin. J. Am. Soc. Nephrol., April 1, 2009; 4(4): 694 - 695. [Full Text] [PDF]