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Published ahead of print on August 20, 2009
Clin J Am Soc Nephrol 4: 1661-1669, 2009
© 2009 American Society of Nephrology
doi: 10.2215/CJN.03180509
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Mini-Reviews

Immunosuppressive Drugs and Tregs: A Critical Evaluation!

Sacha A. De Serres, Mohamed H. Sayegh, and Nader Najafian

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts

Correspondence: Dr. Nader Najafian, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115. Phone: 617-732-7253; Fax: 617-732-5254; E-mail: nnajafian{at}rics.bwh.harvard.edu

To define therapeutic strategies that promote tolerance, it is of critical importance to determine the effects of immunosuppressive drugs on regulatory T cells (Tregs). This review discusses the current knowledge about the physiology of Tregs in humans, the role or Tregs in transplantation, and the impact of the different types of immunosuppressive agents on the frequency and functionality of Tregs in in vitro and in vivo systems.






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