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The Role of Bone Biopsy in Patients with Chronic Renal Failure

University of Colorado Health Sciences Center, Colorado Center for Bone Research, Lakewood, Colorado

Address correspondence to: Dr. Paul D. Miller, Colorado Center for Bone Research, 3190 S. Wadsworth Boulevard, #250, Lakewood, CO 80227. Phone: 303-980-9985; Fax: 303-980-1367; E-mail: millerccbr{at}aol.com

Renal bone disease is a heterogeneous group of metabolic bone diseases that requires quantitative bone histomorphometry to make the correct differential diagnosis. Included in this group is osteoporosis. However, osteoporosis in stage 4 to 5 chronic kidney disease cannot be diagnosed on the basis of bone mineral density criteria established by the World Health Organization or the presence of fragility fractures because patients with all forms of renal bone disease can demonstrate low bone mineral density and fragility fractures. Clinical cases in patients with either low bone mineral density and/or low-trauma fractures will be used to demonstrate the value of bone biopsy and quantitative histomorphometry in making a diagnosis of the specific renal bone disease and assisting with subsequent management decisions.