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Utility and Limitations of a Multicenter Nocturnal Home Hemodialysis Cohort

Robert P. Pauly^*, Michael Copland, Paul Komenda, Adeera Levin^,, Andreas Pierratos^||, and Christopher T. Chan^¶

^* Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Department of Medicine, Division of Nephrology, University of British Columbia, and British Columbia Renal Agency, Vancouver, British Columbia, Department of Medicine, Division of Nephrology, University of Manitoba, Winnipeg, Manitoba, and ^|| Humber River Regional Hospital and ^¶ University Health Network–Toronto General Hospital, Department of Medicine, Division of Nephrology, University of Toronto, Toronto, Ontario, Canada

Correspondence: Dr. Robert P. Pauly, Department of Medicine, Division of Nephrology and Immunology, 8440 112th Avenue, 11-107 Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada. Phone: 780-407-3218; Fax: 780-407-7878; E-mail: robert.pauly{at}ualberta.ca

Nocturnal home hemodialysis (NHD) is the most intensive dialysis strategy among dialytic renal replacement options and is receiving increased attention as more research reveals its physiologic restorative potential compared with conventional hemodialysis; however, a significant gap in knowledge remains concerning the predictors of program success and the clinical outcomes of NHD. This review aims to highlight the methodologic strengths and pitfalls of various study designs as they pertain to NHD research and lays the foundation for the CANandian Slow Long nightly ExtEnded dialysis Programs (CAN-SLEEP), a multicenter NHD research network aimed to facilitate investigation of NHD.