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This Article Full Text Full Text (PDF) All Versions of this Article: CJN.00800208v1 3/5/1296    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Chonchol, M. Articles by Targher, G. PubMed PubMed Citation Articles by Chonchol, M. Articles by Targher, G.

Prevalence of Subclinical Hypothyroidism in Patients with Chronic Kidney Disease

Michel Chonchol^*, Giuseppe Lippi, Gianluca Salvagno, Giacomo Zoppini, Michele Muggeo, and Giovanni Targher

^* Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado; Section of Clinical Chemistry, Department of Biomedical and Morphological Sciences, and Section of Endocrinology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy

Correspondence: Dr. Michel Chonchol, University of Colorado Health Sciences Center, Division of Renal Diseases and Hypertension, Box C-281, Denver, CO 80262. Phone: 303-399-6997; Fax: 303-399-3131; E-mail: Michel.Chonchol{at}uchsc.edu

Background and objectives: Subclinical primary hypothyroidism is highly prevalent in the general population, especially in the elderly. However, the prevalence of subclinical primary hypothyroidism in persons with chronic kidney disease (CKD) not requiring chronic dialysis is not well defined.

Design, setting, participants, and measurements: Cross-sectional data from 3089 adult outpatients, who were consecutively referred by general practitioners for routine blood testing over the last two years, were analyzed. Glomerular filtration rate (GFR) was estimated by the abbreviated Modification of Diet in Renal Disease equation. Multivariable logistic regression was used to evaluate the independent association between prevalent subclinical primary hypothyroidism and estimated GFR.

Results: Among 3089 adult participants, 293 (9.5%) had subclinical primary hypothyroidism and 277 (9%) had an estimated GFR <60 ml/min per 1.73 m². The prevalence of subclinical primary hypothyroidism increased from 7% at an estimated GFR 90 ml/min per 1.73 m² to 17.9% at an estimated GFR <60 ml/min per 1.73 m² (P < 0.0001 for trend). Compared with participants with an estimated GFR 60 ml/min per 1.73 m², those with estimated GFR <60 ml/min per 1.73 m² had an increased odds of subclinical primary hypothyroidism after adjusting for age, gender, fasting plasma glucose, total cholesterol, and triglyceride concentrations.

Conclusions: These findings suggest that subclinical primary hypothyroidism is a relatively common condition (18%) among persons with CKD not requiring chronic dialysis, and it is independently associated with progressively lower estimated GFR in a large cohort of unselected outpatient adults.

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				A. Connor and J. E. Taylor Renal impairment resulting from hypothyroidism NDT Plus, December 1, 2008; 1(6): 440 - 441. [Full Text] [PDF]