HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: CJN.03190807v1 3/2/331    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Perianayagam, A. Articles by Kouides, R. Search for Related Content PubMed PubMed Citation Articles by Perianayagam, A. Articles by Kouides, R.

DDAVP Is Effective in Preventing and Reversing Inadvertent Overcorrection of Hyponatremia

Anjana Perianayagam^*, Richard H. Sterns^*,, Stephen M. Silver^*,, Marvin Grieff^*,, Robert Mayo^*,, John Hix^*,, and Ruth Kouides^*,

^* Rochester General Hospital, Department of Medicine, and University of Rochester School of Medicine and Dentistry, Rochester, New York

Correspondence: Dr. Richard H. Sterns, 1425 Portland Avenue, Rochester NY 14621. Phone: 585-922-4242; Fax: 585-922-4440; E-mail: richard.sterns{at}viahealth.org

Background and objectives: Adherence to therapeutic guidelines for the treatment of hyponatremia becomes difficult when water diuresis emerges during therapy. The objective of this study was to assess the effectiveness and safety of desmopressin acetate as a therapeutic agent to avoid overcorrection of hyponatremia and to lower the plasma sodium concentration again after inadvertent overcorrection.

Design, setting, participants, & measurements: Retrospective chart review was conducted of all patients who were given desmopressin acetate during the treatment of hyponatremia during 6 yr in a 528-bed community teaching hospital.

Results: Six patients (group 1) were given desmopressin acetate after the 24-h limit of 12 mmol/L had already been reached or exceeded; correction was prevented from exceeding the 48-h limit of 18 mmol/L in five of the six. Fourteen patients (group 2) were given desmopressin acetate in anticipation of overcorrection after the plasma sodium concentration had increased by 1 to 12 mmol/L. In all 14 patients who were treated with desmopressin acetate as a preventive measure, correction was prevented from exceeding either the 24- or 48-h limits. After desmopressin acetate was administered, the plasma sodium concentration of 14 of the 20 patients fell by 2 to 9 mmol/L. In all six group 1 patients and in five of the group 2 patients, the plasma sodium concentration was actively lowered again by the concurrent administration of desmopressin acetate and 5% dextrose in water; no serious adverse consequences from this maneuver were observed.

Conclusion: Desmopressin acetate is effective in preventing and reversing inadvertent overcorrection of hyponatremia.

This article has been cited by other articles:

				N. van der Lubbe, C. J. Thompson, R. Zietse, and E. J. Hoorn The clinical challenge of SIADH--three cases NDT Plus, November 1, 2009; 2(suppl_3): iii20 - iii24. [Abstract] [Full Text] [PDF]