CJASN
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published ahead of print on October 10, 2007
Clin J Am Soc Nephrol 2: 1241-1248, 2007
© 2007 American Society of Nephrology
doi: 10.2215/CJN.02190507
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
CJN.02190507v1
2/6/1241    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sigrist, M. K.
Right arrow Articles by McIntyre, C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sigrist, M. K.
Right arrow Articles by McIntyre, C. W.

Mineral Metabolism and Bone Disease

Progressive Vascular Calcification over 2 Years Is Associated with Arterial Stiffening and Increased Mortality in Patients with Stages 4 and 5 Chronic Kidney Disease

Mhairi K. Sigrist*,{dagger}, Maarten W. Taal*,{dagger}, Peter Bungay{ddagger}, and Christopher W. McIntyre*,{dagger}

Departments of * Renal Medicine and {ddagger} Imaging, Derby City General Hospital, Derby, and {dagger} School of Health, University of Nottingham, Nottingham, United Kingdom

Correspondence: Dr. Christopher W. McIntyre, Department of Renal Medicine, Derby City General Hospital, Derby, DE22 3NE, UK. Phone: +44-01332-625675; Fax: +44-01332-625975; E-mail: Chris.McIntyre{at}nottingham.ac.uk

Background and objectives: Vascular calcification is increasingly recognized as an important component of cardiovascular disease in chronic kidney disease. The objective of this study was to investigate prospectively the determinants, cardiovascular functional consequences, and survival associated with vascular calcification over 24 mo.

Design, setting, participants, & measurements: A total of 134 patients (60 on hemodialysis, 28 on peritoneal dialysis, and 46 with stage 4 chronic kidney disease) were studied. Vascular calcification of the superficial femoral artery was assessed using multislice spiral computed tomography; pulse wave velocity; all medications and time-averaged biochemical parameters were recorded at baseline and 12 and 24 mo.

Results: A total of 101 patients remained at 24 mo. Progressive calcification was seen in 58 of 101 patients. Most (31 of 46) patients with an initial calcification score of zero did not develop calcification. The hemodialysis group demonstrated a greater degree of progression than patients who were on peritoneal dialysis or had stage 4 chronic kidney disease. Progressive calcification was associated with age, male gender, serum alkaline phosphatase, ß blockers, and lipid-lowering agents. Increases in vascular calcification correlated with increased arterial stiffness. Vascular calcification was present in 20 of 21 patients who died. Cox proportional hazard analysis identified change in calcification score, calcium intake from phosphate binders, and low albumin as risk factors for death.

Conclusions: Patients with stages 4 and 5 chronic kidney disease and preexisting vascular calcification exhibit significantly increased calcification over 24 mo. Rapid progression of calcification is associated with arterial stiffness and mortality.




This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. Ketteler and P. H. Biggar
What dishwashers and humans have in common?
Nephrol. Dial. Transplant., November 5, 2009; (2009) gfp541v1.
[Full Text] [PDF]

Home page
 CJASNHome page
S. Beddhu, X. Ma, B. Baird, A. K. Cheung, and T. Greene
Serum Alkaline Phosphatase and Mortality in African Americans with Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol., November 1, 2009; 4(11): 1805 - 1810.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. K. Sigrist, A. Levin, L. Er, and C. W. McIntyre
Elevated osteoprotegerin is associated with all-cause mortality in CKD stage 4 and 5 patients in addition to vascular calcification
Nephrol. Dial. Transplant., October 1, 2009; 24(10): 3157 - 3162.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
L. Labriola, P. Wallemacq, B. Gulbis, and M. Jadoul
The impact of the assay for measuring albumin on corrected ('adjusted') calcium concentrations
Nephrol. Dial. Transplant., June 1, 2009; 24(6): 1834 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
R. N. Foley
Phosphate Levels and Cardiovascular Disease in the General Population
Clin. J. Am. Soc. Nephrol., June 1, 2009; 4(6): 1136 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
V. Belozeroff, W. G. Goodman, L. Ren, and K. Kalantar-Zadeh
Cinacalcet Lowers Serum Alkaline Phosphatase in Maintenance Hemodialysis Patients
Clin. J. Am. Soc. Nephrol., March 1, 2009; 4(3): 673 - 679.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. M. McEniery, B. J. McDonnell, A. So, S. Aitken, C. E. Bolton, M. Munnery, S. S. Hickson, Yasmin, K. M. Maki-Petaja, J. R. Cockcroft, et al.
Aortic Calcification Is Associated With Aortic Stiffness and Isolated Systolic Hypertension in Healthy Individuals
Hypertension, March 1, 2009; 53(3): 524 - 531.
[Abstract] [Full Text] [PDF]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
S. Brincat and D. J. Goldsmith
Review: Vascular calcification in chronic kidney disease: the tip of the chalk-berg
The British Journal of Diabetes & Vascular Disease, November 1, 2008; 8(6): 264 - 271.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society of Nephrology.