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Early Intervention Improves Mortality and Hospitalization Rates in Incident Hemodialysis Patients: RightStart Program

Rebecca L. Wingard^*, Lara B. Pupim^,, Mahesh Krishnan, Ayumi Shintani, T. Alp Ikizler, and Raymond M. Hakim^*

^* Fresenius Medical Care–North America, Inc., and Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee; and Amgen, Inc., Thousand Oaks, California

Correspondence: Dr. T. Alp Ikizler, Vanderbilt University Medical Center, 1161 First Avenue South & Garland, Division of Nephrology, S-3223 MCN, Nashville, TN 37232-2372. Phone: 615-343-6104; Fax: 615-343-7156; E-mail: alp.ikizler{at}vanderbilt.edu

Background and objectives: Annualized mortality rates of chronic hemodialysis (CHD) patients in their first 90 d of treatment range from 24 to 50%. Limited studies also show high hospitalization rates. It was hypothesized that a structured quality improvement program (RightStart), focused on medical needs and patient education and support, would improve outcomes for incident CHD patients.

Design, setting, participants, & measurements: A total of 918 CHD incident patients were prospectively enrolled in a multicenter RightStart Program, and compared with a time-concurrent group of 1020 control patients from non-RightStart clinics. RightStart patients received 3 mo of intervention in management of anemia, dosage of dialysis, nutrition, and dialysis access and a comprehensive educational program. Outcomes were tracked for up to 12 mo.

Results: At 3 mo, RightStart patients had higher albumin and hematocrit values. Dose of dialysis and permanent access placement were not statistically significantly different from control subjects. Compared with baseline, Mental Composite Score for RightStart patients improved significantly. Mean hospitalization days per patient year were reduced with RightStart versus control subjects. Mortality rates at 3, 6, and 12 mo were 20, 18, and 17 for RightStart patients versus 39, 33, and 30 deaths per 100 patient-years for control subjects, respectively.

Conclusions: A structured program of prompt medical and educational strategies in incident CHD patients results in improved morbidity and mortality that last up to 1 yr.

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Value of Quality Improvement Reporting

Kirsten L. Johansen
Clin. J. Am. Soc. Nephrol. 2007 2: 1104-1105. [Full Text] [PDF]

This article has been cited by other articles:

				K. L. Cavanaugh, R. L. Wingard, R. M. Hakim, T. A. Elasy, and T. A. Ikizler Patient Dialysis Knowledge Is Associated with Permanent Arteriovenous Access Use in Chronic Hemodialysis Clin. J. Am. Soc. Nephrol., May 1, 2009; 4(5): 950 - 956. [Abstract] [Full Text] [PDF]

				K. L. Johansen Value of Quality Improvement Reporting Clin. J. Am. Soc. Nephrol., November 1, 2007; 2(6): 1104 - 1105. [Full Text] [PDF]