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Aldosteronism and Hypertension

Vascular Biology and Hypertension Program, Sleep/Wake Disorders Center, University of Alabama at Birmingham, Birmingham, Alabama

Address correspondence to: Dr. David A. Calhoun, 430 BMR2, 1530 3rd Avenue South, Birmingham, AL 35294-2180; Phone: 205-934-4633; Fax: 205-996-2586; dcalhoun{at}uab.edu

A growing body of evidence suggests that hyperaldosteronism contributes significantly to the development and the severity of hypertension as well as to resistance to antihypertensive treatment. In cross-sectional analyses, plasma aldosterone levels have been shown to relate to BP levels, particularly in obese individuals. In these same individuals, BP was not related to plasma renin activity, suggesting an effect of aldosterone on BP independent of renin–angiotensin II. In a recent prospective analysis from the Framingham investigators, baseline serum aldosterone was strongly associated with development of hypertension during a 4-yr follow-up.

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