Table 3. Comparison of response to second-line agents on the basis of steroid responsiveness
| Second-Line Agent |
Total No. Treateda |
Steroid Dependent (n) |
Steroid Resistant (n) |
Pb |
|
| Cyclophosphamide |
20 |
5 |
4 |
|
| total remission (n [%]) |
11 (55) |
4 (80) |
2 (50) |
0.081 |
| complete (n) |
8 |
3 |
1 |
|
| partial (n) |
3 |
1 |
1 |
|
| Cyclosporine |
39 |
8 |
20 |
|
| total remission (n [%]) |
24 (61) |
6 (75) |
9 (45) |
0.064 |
| complete (n) |
14 |
5 |
4 |
|
| partial (n) |
10 |
1 |
5 |
|
| Tacrolimus |
4 |
2 |
2 |
|
| total remission (n [%]) |
3 (75) |
2 (100) |
1 (50) |
0.076 |
| complete (n) |
1 |
1 |
0 |
|
| partial (n) |
2 |
1 |
1 |
|
| Mycophenolate mofetil |
14 |
7 |
4 |
|
| total remission (n [%]) |
9 (64) |
6 (86) |
1 (25) |
0.055 |
| complete (n) |
5 |
4 |
0 |
|
| partial (n) |
4 |
2 |
1 |
|
| All agents combined |
77 |
22 |
30 |
|
| total remission (n [%]) |
47 (61) |
18 (82) |
13 (43) |
0.010 |
| complete (n) |
28 |
13 |
5 |
|
| partial (n) |
18 |
5 |
8 |
|
|
a Total no. treated includes all patients who were treated for any indication, including steroid resistance or dependence, partial response to steroids, frequent relapses, or toxicity/contraindications to steroids.
b Steroid dependent versus steroid resistant.